Low electric fields induce ligand-independent activation of EGF receptor and ERK via electrochemical elevation of H⁺ and ROS concentrations

Keyphrases

• Epidermal Growth Factor Receptor 100%
• EGF Receptor 100%
• Ligand-independent Activation 100%
• Low Electric Field 100%
• Receptor Activation 42%
• Epidermal Growth Factor Receptor Ligands 28%
• Ligandless 28%
• Electric Field (E-field) 14%
• Starvation 14%
• Long-term Exposure 14%
• ERK Activation 14%
• Mitogen-activated Protein Kinase 14%
• Receptor Signaling 14%
• Reactive Oxygen Species 14%
• Biological Processes 14%
• Receptor Tyrosine Kinase 14%
• Dimerization 14%
• Possible Mechanisms 14%
• Electric-field-induced 14%
• Downstream Signaling 14%
• Ligand-independent 14%
• Independent Pathway 14%
• Intracellular Signaling 14%
• Ligand Binding Site 14%
• Growth Factor Receptor Tyrosine Kinase 14%
• Neutralizing Antibodies 14%
• Pulse Width 14%
• Receptor-independent 14%
• Serum-free Medium 14%
• Receptor-ligand Binding 14%
• Physiological Electric Field 14%

Biochemistry, Genetics and Molecular Biology

• Epidermal Growth Factor Receptor 100%
• Electric Field 100%
• Pulse Rate 9%
• Binding Site 9%
• Biological Phenomena and Functions Concerning the Entire Organism 9%
• Dimerization 9%
• Receptor Tyrosine Kinase 9%
• Independent Pathway 9%
• Ligand Binding 9%
• Intracellular Signaling 9%
• Neutralizing Antibody 9%
• MAPK Signaling 9%

Neuroscience

• Epidermal Growth Factor Receptor 100%
• Binding Site 9%
• Ligand Binding 9%
• Reactive Oxygen Species 9%
• Receptor Tyrosine Kinase 9%
• Intracellular Signaling 9%
• MAPK Signaling 9%
• Neutralizing Antibody 9%