Low electric field enhanced chemotherapy can cure mice with CT-26 colon carcinoma and induce anti-tumour immunity

A. Plotnikov; D. Fishman; T. Tichler; R. Korenstein; Yona Keisari

doi:10.1111/j.1365-2249.2004.02636.x

Low electric field enhanced chemotherapy can cure mice with CT-26 colon carcinoma and induce anti-tumour immunity

A. Plotnikov, D. Fishman, T. Tichler, R. Korenstein, Yona Keisari^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Low electric field cancer treatment - enhanced chemotherapy (LEFCT-EC) is a new anticancer treatment which utilizes a combination of chemotherapeutic agents and a low electric field. We investigated the antitumour effectiveness of this technique in a model of murine colon carcinoma (CT-26). The low electric field was applied to ∼65 mm³ intracutaneous tumours after intratumoral injection of 5FU, bleomycin or BCNU. We observed significant tumour size reduction and a prolongation of survival time. The complete cure of a significant fraction of animals treated by LEFCT-EC with 5FU (33%), bleomycin (51%) or BCNU (83%) was observed. Mice cured by LEFCT-EC developed resistance to a tumour challenge and their splenocytes had antitumour activity in vivo. Our results suggest that LEFCT-EC is an effective method for treatment of solid tumours.

Original language	English
Pages (from-to)	410-416
Number of pages	7
Journal	Clinical and Experimental Immunology
Volume	138
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2249.2004.02636.x
State	Published - Dec 2004

Keywords

Chemotherapy
Colon cancer
Electrostimulation
Immunostimulation
Low electric field

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10.1111/j.1365-2249.2004.02636.x

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abstract = "Low electric field cancer treatment - enhanced chemotherapy (LEFCT-EC) is a new anticancer treatment which utilizes a combination of chemotherapeutic agents and a low electric field. We investigated the antitumour effectiveness of this technique in a model of murine colon carcinoma (CT-26). The low electric field was applied to ∼65 mm3 intracutaneous tumours after intratumoral injection of 5FU, bleomycin or BCNU. We observed significant tumour size reduction and a prolongation of survival time. The complete cure of a significant fraction of animals treated by LEFCT-EC with 5FU (33%), bleomycin (51%) or BCNU (83%) was observed. Mice cured by LEFCT-EC developed resistance to a tumour challenge and their splenocytes had antitumour activity in vivo. Our results suggest that LEFCT-EC is an effective method for treatment of solid tumours.",

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AU - Korenstein, R.

AU - Keisari, Yona

PY - 2004/12

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N2 - Low electric field cancer treatment - enhanced chemotherapy (LEFCT-EC) is a new anticancer treatment which utilizes a combination of chemotherapeutic agents and a low electric field. We investigated the antitumour effectiveness of this technique in a model of murine colon carcinoma (CT-26). The low electric field was applied to ∼65 mm3 intracutaneous tumours after intratumoral injection of 5FU, bleomycin or BCNU. We observed significant tumour size reduction and a prolongation of survival time. The complete cure of a significant fraction of animals treated by LEFCT-EC with 5FU (33%), bleomycin (51%) or BCNU (83%) was observed. Mice cured by LEFCT-EC developed resistance to a tumour challenge and their splenocytes had antitumour activity in vivo. Our results suggest that LEFCT-EC is an effective method for treatment of solid tumours.

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KW - Colon cancer

KW - Electrostimulation

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KW - Low electric field

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Low electric field enhanced chemotherapy can cure mice with CT-26 colon carcinoma and induce anti-tumour immunity

Abstract

Keywords

UN SDGs

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