Low electric field enhanced chemotherapy can cure mice with CT-26 colon carcinoma and induce anti-tumour immunity

A. Plotnikov, D. Fishman, T. Tichler, R. Korenstein, Yona Keisari*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Low electric field cancer treatment - enhanced chemotherapy (LEFCT-EC) is a new anticancer treatment which utilizes a combination of chemotherapeutic agents and a low electric field. We investigated the antitumour effectiveness of this technique in a model of murine colon carcinoma (CT-26). The low electric field was applied to ∼65 mm3 intracutaneous tumours after intratumoral injection of 5FU, bleomycin or BCNU. We observed significant tumour size reduction and a prolongation of survival time. The complete cure of a significant fraction of animals treated by LEFCT-EC with 5FU (33%), bleomycin (51%) or BCNU (83%) was observed. Mice cured by LEFCT-EC developed resistance to a tumour challenge and their splenocytes had antitumour activity in vivo. Our results suggest that LEFCT-EC is an effective method for treatment of solid tumours.

Original languageEnglish
Pages (from-to)410-416
Number of pages7
JournalClinical and Experimental Immunology
Volume138
Issue number3
DOIs
StatePublished - Dec 2004

Keywords

  • Chemotherapy
  • Colon cancer
  • Electrostimulation
  • Immunostimulation
  • Low electric field

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