TY - JOUR
T1 - Low dose naloxone for pruritus in systemic sclerosis
T2 - Case series and literature review
AU - Meridor, Katya
AU - Berookhim, Joshua
AU - Levy, Yair
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/1/28
Y1 - 2022/1/28
N2 - Rationale:Pruritus is a common symptom in patients with systemic sclerosis and has a tremendous effect on the quality of life. Nevertheless, current therapeutic options are limited. The pathogenesis of pruritus in systemic sclerosis is not completely understood; however, opiate-mediated neurotransmission has been postulated to be involved.Patient concerns and diagnosis:We describe 4 female patients with systemic sclerosis suffering from severe pruritus, with an average 5D-itch score of 22.75.Intervention and outcomes:Low-dose oral naloxone was initiated, followed by a significant improvement in the level of pruritus, reaching an average 5D-itch score of 7.5, after 6 and 12 months of treatment. None of the patients experienced side effects.Lessons:Low-dose naloxone plays an important role in the management of pruritus in systemic sclerosis.
AB - Rationale:Pruritus is a common symptom in patients with systemic sclerosis and has a tremendous effect on the quality of life. Nevertheless, current therapeutic options are limited. The pathogenesis of pruritus in systemic sclerosis is not completely understood; however, opiate-mediated neurotransmission has been postulated to be involved.Patient concerns and diagnosis:We describe 4 female patients with systemic sclerosis suffering from severe pruritus, with an average 5D-itch score of 22.75.Intervention and outcomes:Low-dose oral naloxone was initiated, followed by a significant improvement in the level of pruritus, reaching an average 5D-itch score of 7.5, after 6 and 12 months of treatment. None of the patients experienced side effects.Lessons:Low-dose naloxone plays an important role in the management of pruritus in systemic sclerosis.
KW - naloxone
KW - opiate antagonists
KW - pruritus
KW - systemic sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85123901337&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000028653
DO - 10.1097/MD.0000000000028653
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C2 - 35089206
AN - SCOPUS:85123901337
SN - 0025-7974
VL - 101
SP - E28653
JO - Medicine (United States)
JF - Medicine (United States)
IS - 4
ER -