TY - JOUR
T1 - Low ALT blood levels predict long-term all-cause mortality among adults. A historical prospective cohort study
AU - Ramaty, E.
AU - Maor, E.
AU - Peltz-Sinvani, N.
AU - Brom, A.
AU - Grinfeld, A.
AU - Kivity, S.
AU - Segev, S.
AU - Sidi, Y.
AU - Kessler, T.
AU - Sela, B. A.
AU - Segal, G.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background Increased blood levels of alanine amino transferase (ALT, also known as SGPT; serum glutamic pyruvic transaminase) serve as a marker of liver injury by various mechanisms. Less is known about the clinical implications associated with low-normal ALT levels. Previous studies showed low ALT levels to be associated with poor long-term outcomes among elderlies, serving as a biomarker for increased incidence of frailty and subsequent risk of mortality. However, it has not been determined yet whether low-normal ALT values might be predictive of frailty and mortality in younger, middle-aged adults. 2014 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.Methods We conducted a historical prospective cohort analysis.Results A total of 23,506 adults with ALT levels within the normal range, at the mean age of 48 ± 11 years, participating in an annual screening program for preventive medicine, were followed-up for a median period of 8.5 years during which 638 died. Low-normal ALT values (serum ALT activity < 17 IU/L) were found to be predictive for increased risk of all-cause mortality (HR = 1.6; 95% CI 1.34-1.92; p < 0.001). Statistically significant correlation was demonstrated even after applying a multifactorial model correction for age, gender, eGFR, low albumin, arterial hypertension, diabetes mellitus and ischemic heart disease.Conclusions We suggest that low-normal ALT values may serve as an independent predictive marker for increased long-term mortality in middle-aged adults.
AB - Background Increased blood levels of alanine amino transferase (ALT, also known as SGPT; serum glutamic pyruvic transaminase) serve as a marker of liver injury by various mechanisms. Less is known about the clinical implications associated with low-normal ALT levels. Previous studies showed low ALT levels to be associated with poor long-term outcomes among elderlies, serving as a biomarker for increased incidence of frailty and subsequent risk of mortality. However, it has not been determined yet whether low-normal ALT values might be predictive of frailty and mortality in younger, middle-aged adults. 2014 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.Methods We conducted a historical prospective cohort analysis.Results A total of 23,506 adults with ALT levels within the normal range, at the mean age of 48 ± 11 years, participating in an annual screening program for preventive medicine, were followed-up for a median period of 8.5 years during which 638 died. Low-normal ALT values (serum ALT activity < 17 IU/L) were found to be predictive for increased risk of all-cause mortality (HR = 1.6; 95% CI 1.34-1.92; p < 0.001). Statistically significant correlation was demonstrated even after applying a multifactorial model correction for age, gender, eGFR, low albumin, arterial hypertension, diabetes mellitus and ischemic heart disease.Conclusions We suggest that low-normal ALT values may serve as an independent predictive marker for increased long-term mortality in middle-aged adults.
KW - ALT
KW - Frailty
KW - Mortality
KW - SGPT
KW - Screening
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84915751837&partnerID=8YFLogxK
U2 - 10.1016/j.ejim.2014.10.019
DO - 10.1016/j.ejim.2014.10.019
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C2 - 25468741
AN - SCOPUS:84915751837
SN - 0953-6205
VL - 25
SP - 919
EP - 921
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
IS - 10
ER -
