@article{c329942e6991416b9a00a718ce540c54,
title = "Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning",
abstract = "Bilateral kainic acid lesions of the ventral globus pallidus produced a significant and selective cortical decrease in choline acetyltransferase activity in the rat brain. When lesioned and control subjects were compared on performance of a step-through passive avoidance task, lesioned rats showed a marked retention deficit 24 hr after the initial training trial. This experimentally-induced memory deficit associated with a cortical cholinergic neuronal loss resembles the deficits in senile dementia of the Alzheimer type and may provide a useful animal model for studying the disease.",
keywords = "Alzheimer disease, Cortical choline acetyltransferase, Memory deficit, N basalis lesion",
author = "Eitan Friedman and Barbara Lerer and Joan Kuster",
note = "Funding Information: Animals were trained and tested 14-16 days post-operatively on a 24 hr passive-avoidance task. Each rat was individually placed in the lighted front compartment of a two-compartment shuttle box. Electromechanical switching circuitry was used to measure the subject's latency to enter the dark compartment of the shuttle box. When a subject had been in the dark rear compartment for 5 sec, a 1.5 mA scrambled foot-shock (Lafayette) was applied to the metal grid bars of the floor until the subject escaped through the doorway to the lighted front compartment. If the subject 'Preliminary results have been presented at the 12th Annual Society for Neuroscience meeting, Minneapolis, M N, October 31, 1982 and The 10th Aharon Katzir-Katchalsky Conference on the Aging of the Brain, Mantova, Italy, March 26, 1982. This research is supported in part by U.S.P.H.S., RSDA MH 00208, grants 5T 32MH15137 and MHCRC MH 35976.",
year = "1983",
month = aug,
doi = "10.1016/0091-3057(83)90057-6",
language = "אנגלית",
volume = "19",
pages = "309--312",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "2",
}