Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning

Eitan Friedman, Barbara Lerer, Joan Kuster

Research output: Contribution to journalArticlepeer-review

Abstract

Bilateral kainic acid lesions of the ventral globus pallidus produced a significant and selective cortical decrease in choline acetyltransferase activity in the rat brain. When lesioned and control subjects were compared on performance of a step-through passive avoidance task, lesioned rats showed a marked retention deficit 24 hr after the initial training trial. This experimentally-induced memory deficit associated with a cortical cholinergic neuronal loss resembles the deficits in senile dementia of the Alzheimer type and may provide a useful animal model for studying the disease.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume19
Issue number2
DOIs
StatePublished - Aug 1983
Externally publishedYes

Keywords

  • Alzheimer disease
  • Cortical choline acetyltransferase
  • Memory deficit
  • N basalis lesion

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