Long‐Term Opiate Exposure Leads to Reduction of the αi‐1 Sufyunit of GTP‐Binding Proteins

Bernard Attali, Zvi Vogel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: Desensitization or tolerance is a major consequence of long‐term opiate exposure. The mechanism of opiate desensitization is only poorly understood. We report that exposure of raj spinal cord‐dorsal root ganglion cocultured neurons to k‐opiate agonists is accompanied by a 60–70% reduction in the level of the αi subunit of GTP‐binding proteins. Using selective antibodies, which discriminate among the various αi subunit forms, it was found that the opiate treatment leads to a reduction in the amount of the αi‐1 subunit. The levels of αs, αo, and β subunits remain unchanged. Tnis molecular event could underlie the development of tolerance and cross‐tolerance to opiates.

Original languageEnglish
Pages (from-to)1636-1639
Number of pages4
JournalJournal of Neurochemistry
Volume53
Issue number5
DOIs
StatePublished - Nov 1989
Externally publishedYes

Keywords

  • Adenylate cyclase
  • Desensitization
  • GTP‐binding proteins
  • Opiate receptors
  • Opiate tolerance
  • Spinal cord

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