TY - JOUR
T1 - Longitudinal changes in bone mineral density in children with inflammatory bowel diseases
AU - Levy-Shraga, Yael
AU - Shenkar, Anatoly
AU - Modan-Moses, Dalit
AU - Assa, Amit
AU - Haberman, Yael
AU - Shouval, Dror
AU - Guz-Mark, Anat
AU - Lahad, Avishay
AU - Weiss, Batia
N1 - Publisher Copyright:
© 2019 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Aim: Children with inflammatory bowel disease (IBD) are prone to low bone mineral density (BMD). Our aim was to assess longitudinal changes in BMD in this population. Methods: A retrospective longitudinal study of children with IBD, treated at two tertiary centres in Israel, who underwent two BMD measurements by dual-energy X-ray absorptiometry (DXA). Changes in lumbar spine BMD (∆L1-4 z-scores) were examined for correlations with clinical characteristics. Results: The cohort included 41 patients (age at diagnosis 12.1 ± 3.5 years, 23 females).The mean interval between the scans was 3.4 ± 2.0 years. There was a trend towards improvement in L1-4 z-scores (−1.64 ± 1.02 vs −1.45 ± 0.83, P =.12). ∆L1-4 z-scores correlated positively with ∆weight-standard deviation scores (SDS), ∆height-SDS and ∆BMI-SDS, and with age at the second scan (R =.55, P <.01; R =.42, P <.01; R =.42, P =.01; R =.35, P =.02, respectively); and negatively with L1-4 z-scores at the first scan (R = −.63, P <.01). Stepwise linear regression analysis identified the first scan L1-4 z-scores and ∆weight-SDS as independent predictors of ∆L1-4 z-scores. An L1-4 z-score ≤−2 at the first DXA scan was associated with significant improvement at the second scan. Conclusion: Improvement in BMD was more pronounced in children who gained weight or whose BMD was low at the first scan.
AB - Aim: Children with inflammatory bowel disease (IBD) are prone to low bone mineral density (BMD). Our aim was to assess longitudinal changes in BMD in this population. Methods: A retrospective longitudinal study of children with IBD, treated at two tertiary centres in Israel, who underwent two BMD measurements by dual-energy X-ray absorptiometry (DXA). Changes in lumbar spine BMD (∆L1-4 z-scores) were examined for correlations with clinical characteristics. Results: The cohort included 41 patients (age at diagnosis 12.1 ± 3.5 years, 23 females).The mean interval between the scans was 3.4 ± 2.0 years. There was a trend towards improvement in L1-4 z-scores (−1.64 ± 1.02 vs −1.45 ± 0.83, P =.12). ∆L1-4 z-scores correlated positively with ∆weight-standard deviation scores (SDS), ∆height-SDS and ∆BMI-SDS, and with age at the second scan (R =.55, P <.01; R =.42, P <.01; R =.42, P =.01; R =.35, P =.02, respectively); and negatively with L1-4 z-scores at the first scan (R = −.63, P <.01). Stepwise linear regression analysis identified the first scan L1-4 z-scores and ∆weight-SDS as independent predictors of ∆L1-4 z-scores. An L1-4 z-score ≤−2 at the first DXA scan was associated with significant improvement at the second scan. Conclusion: Improvement in BMD was more pronounced in children who gained weight or whose BMD was low at the first scan.
KW - Crohn's disease
KW - bone
KW - bone mineral density
KW - dual-energy X-ray absorptiometry
KW - ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85074657386&partnerID=8YFLogxK
U2 - 10.1111/apa.15046
DO - 10.1111/apa.15046
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C2 - 31594031
AN - SCOPUS:85074657386
SN - 0803-5253
VL - 109
SP - 1026
EP - 1032
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 5
ER -