Longitudinal assessment of deliberate mouse behavior in the home cage and attached environments: Relevance to anxiety and mood disorders

Martien J. Kas*, Ilan Golani, Yoav Benjamini, Ehud Fonio, Oliver Stiedl

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Understanding behavioral regulation can further progress by developing new approaches that allow refinement of behavioral phenotypes. The current availability of several thousand different mutant mice and of human candidate genes for emotional (affective) disorders challenges behavioral neuroscientists to extend their views and methodologies to dissect complex behaviors into behavioral phenotypes and subsequently to define gene-behavioral phenotype relationships. Here, we put forward multiday automated behavioral and physiological observations in carefully designed environments to assess evolutionary conserved behavioral strategies in mice. This offers the opportunity to design experimental setups that allow the animals themselves to regulate their own behavior, using representations of continuous kinematic variables, studying the dynamics of behavior (change across time or change across activity); i.e., growth or decay processes of behavior and concomitant physiological adjustments such as heart rate. The measures characterizing these processes should have discriminative power (across strains or treatments) and be replicable (across laboratories). Furthermore, cross species genetic studies for these neurobehavioral and physiological traits may provide a novel way toward identifying neurobiological mechanisms underlying core features of complex psychiatric disorders.

Original languageEnglish
Title of host publicationMood and Anxiety Related Phenotypes in Mice
Subtitle of host publicationCharacterization Using Behavioral Tests, Volume II
EditorsTodd Gould
Number of pages20
StatePublished - 2011

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • Arousal
  • Behavioral growth
  • Conditioned fear
  • Dynamics of behavior
  • Exploration
  • Genetics
  • Heart rate
  • Physiology
  • Psychiatry
  • Replicability
  • Sequences of repeated motion


Dive into the research topics of 'Longitudinal assessment of deliberate mouse behavior in the home cage and attached environments: Relevance to anxiety and mood disorders'. Together they form a unique fingerprint.

Cite this