Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Yu Xuan Lyu; Qiang Fu; Dominika Wilczok; Kejun Ying; Aaron King; Adam Antebi; Aleksandar Vojta; Alexandra Stolzing; Alexey Moskalev; Anastasia Georgievskaya; Andrea B. Maier; Andrea Olsen; Anja Groth; Anna Katharina Simon; Anne Brunet; Aisyah Jamil; Anton Kulaga; Asif Bhatti; Benjamin Yaden; Bente Klarlund Pedersen; Björn Schumacher; Boris Djordjevic; Brian Kennedy; Chieh Chen; Christine Yuan Huang; Christoph U. Correll; Coleen T. Murphy; Collin Y. Ewald; Danica Chen; Dario Riccardo Valenzano; Dariusz Sołdacki; David Erritzoe; David Meyer; David A. Sinclair; Eduardo Nunes Chini; Emma C. Teeling; Eric Morgen; Eric Verdin; Erik Vernet; Estefano Pinilla; Evandro F. Fang; Evelyne Bischof; Evi M. Mercken; Fabian Finger; Folkert Kuipers; Frank W. Pun; Gabor Gyülveszi; Gabriele Civiletto; Garri Zmudze; Gil Blander; Harold A. Pincus; Joshua McClure; James L. Kirkland; James Peyer; Jamie N. Justice; Jan Vijg; Jennifer R. Gruhn; Jerry McLaughlin; Joan Mannick; João Passos; Joseph A. Baur; Joe Betts-LaCroix; John M. Sedivy; John R. Speakman; Jordan Shlain; Julia von Maltzahn; Katrin I. Andreasson; Kelsey Moody; Konstantinos Palikaras; Kristen Fortney; Laura J. Niedernhofer; Lene Juel Rasmussen; Liesbeth M. Veenhoff; Lisa Melton; Luigi Ferrucci; Marco Quarta; Maria Koval; Maria Marinova; Mark Hamalainen; Maximilian Unfried; Michael S. Ringel; Milos Filipovic; Mourad Topors; Natalia Mitin; Nawal Roy; Nika Pintar; Nir Barzilai; Paolo Binetti; Parminder Singh; Paul Kohlhaas; Paul D. Robbins; Paul Rubin; Peter O. Fedichev; Petrina Kamya; Pura Muñoz-Canoves; Rafael de Cabo; Richard G.A. Faragher; Rob Konrad; Roberto Ripa; Robin Mansukhani; Sabrina Büttner; Sara A. Wickström; Sebastian Brunemeier; Sergey Jakimov; Shan Luo; Sharon Rosenzweig-Lipson; Shih Yin Tsai; Stefanie Dimmeler; Thomas A. Rando; Tim R. Peterson; Tina Woods; Tony Wyss-Coray; Toren Finkel; Tzipora Strauss; Vadim N. Gladyshev; Valter D. Longo; Varun B. Dwaraka; Vera Gorbunova; Victoria A. Acosta-Rodríguez; Vincenzo Sorrentino; Vittorio Sebastiano; Wenbin Li; Yousin Suh; Alex Zhavoronkov; Morten Scheibye-Knudsen; Daniela Bakula

doi:10.18632/aging.206135

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Yu Xuan Lyu^*
, Qiang Fu
, Dominika Wilczok
, Kejun Ying
, Aaron King
, Adam Antebi
, Aleksandar Vojta
, Alexandra Stolzing
, Alexey Moskalev
, Anastasia Georgievskaya
, Andrea B. Maier
, Andrea Olsen
, Anja Groth
, Anna Katharina Simon
, Anne Brunet
, Aisyah Jamil
, Anton Kulaga
, Asif Bhatti
, Benjamin Yaden
, Bente Klarlund Pedersen

Björn Schumacher, Boris Djordjevic, Brian Kennedy, Chieh Chen, Christine Yuan Huang, Christoph U. Correll, Coleen T. Murphy, Collin Y. Ewald, Danica Chen, Dario Riccardo Valenzano, Dariusz Sołdacki, David Erritzoe, David Meyer, David A. Sinclair, Eduardo Nunes Chini, Emma C. Teeling, Eric Morgen, Eric Verdin, Erik Vernet, Estefano Pinilla, Evandro F. Fang, Evelyne Bischof, Evi M. Mercken, Fabian Finger, Folkert Kuipers, Frank W. Pun, Gabor Gyülveszi, Gabriele Civiletto, Garri Zmudze, Gil Blander, Harold A. Pincus, Joshua McClure, James L. Kirkland, James Peyer, Jamie N. Justice, Jan Vijg, Jennifer R. Gruhn, Jerry McLaughlin, Joan Mannick, João Passos, Joseph A. Baur, Joe Betts-LaCroix, John M. Sedivy, John R. Speakman, Jordan Shlain, Julia von Maltzahn, Katrin I. Andreasson, Kelsey Moody, Konstantinos Palikaras, Kristen Fortney, Laura J. Niedernhofer, Lene Juel Rasmussen, Liesbeth M. Veenhoff, Lisa Melton, Luigi Ferrucci, Marco Quarta, Maria Koval, Maria Marinova, Mark Hamalainen, Maximilian Unfried, Michael S. Ringel, Milos Filipovic, Mourad Topors, Natalia Mitin, Nawal Roy, Nika Pintar, Nir Barzilai, Paolo Binetti, Parminder Singh, Paul Kohlhaas, Paul D. Robbins, Paul Rubin, Peter O. Fedichev, Petrina Kamya, Pura Muñoz-Canoves, Rafael de Cabo, Richard G.A. Faragher, Rob Konrad, Roberto Ripa, Robin Mansukhani, Sabrina Büttner, Sara A. Wickström, Sebastian Brunemeier, Sergey Jakimov, Shan Luo, Sharon Rosenzweig-Lipson, Shih Yin Tsai, Stefanie Dimmeler, Thomas A. Rando, Tim R. Peterson, Tina Woods, Tony Wyss-Coray, Toren Finkel, Tzipora Strauss, Vadim N. Gladyshev, Valter D. Longo, Varun B. Dwaraka, Vera Gorbunova, Victoria A. Acosta-Rodríguez, Vincenzo Sorrentino, Vittorio Sebastiano, Wenbin Li, Yousin Suh, Alex Zhavoronkov^*, Morten Scheibye-Knudsen^*, Daniela Bakula^*

^*Corresponding author for this work

Pediatrics

Southern University of Science and Technology
Max Planck Institute for Biology of Ageing
Binzhou Medical University
Shanghai Jiao Tong University
Shandong Cellogene Pharmaceutics Co. Ltd.
Duke Kunshan University
Duke University
Harvard University
Foresight Institute
University of Cologne
University of Zagreb
Loughborough University
Lobachevsky State University of Nizhni Novgorod
HautAI OÜ
National University of Singapore
California Institute of Technology
University of Copenhagen
Max Delbrück Center for Molecular Medicine in the Helmholtz Association
University of Oxford
Stanford University
Insilico Medicine AI Limited
Romanian Academy
America’s
Indiana University-Purdue University Indianapolis
Biotechnologies Ltd.
University College London
University of California at Los Angeles
The University of Hong Kong
Hofstra
Charité – Universitätsmedizin Berlin
Princeton University
ETH Zurich - Institute for Particle Physics and Astrophysics (IPA)
University of California at Berkeley
Friedrich Schiller University Jena
Longevity Center Europe
Imperial College London
Mayo Clinic Rochester, MN
University College Dublin
BioAge Labs
Buck Institute for Age Research
Research and Early Development
VitaDao
University of Oslo
University of Groningen
Insilico Medicine Hong Kong Ltd.
Rejuveron Life Sciences AG
DSM-Firmenich AG
LongeVC
InsideTracker
Columbia University
Maxwell Biosciences, Inc.
Inc.
XPRIZE Foundation
Albert Einstein College of Medicine
Life Biosciences, Inc.
Cambrian Bio Inc. PipeCo
Mayo Clinic College of Medicine and Science
University of Pennsylvania
Retro Biosciences
Brown University
Shenzhen Institute of Advanced Technology
Private Medical
Brandenburg University of Technology
Inc.
National and Kapodistrian University of Athens
University of Minnesota Twin Cities
Springer Nature
National Institutes of Health
Rubedo Life Sciences
Turn Biotechnologies
Phaedon Institute
University of New South Wales
Longevity Acceleration Fund
Boston Consulting Group
Leibniz-Institut für Analytische Wissenschaften
Inc.
Sapere Bio
Holmusk
AniBiome
Molecule
Gero
University of Montreal
Altos Labs
University of Brighton
Biolytica
Deciduous Therapeutics
Stockholm University
Max Planck Institute for Molecular Biomedicine
Healthspan Capital
Goethe University Frankfurt
Inc.
National Innovation Centre for Ageing
University of Pittsburgh
Sheba Medical Center at Tel Hashomer
University of Southern California
TruDiagnostic, LLC
University of Rochester
University of Texas Southwestern Medical Center
Capital Medical University

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Original language	English
Pages (from-to)	12955-12976
Number of pages	22
Journal	Aging
Volume	16
Issue number	20
DOIs	https://doi.org/10.18632/aging.206135
State	Published - 2024

Funding

Funders	Funder number
Li Ka Shing Faculty of Medicine, University of Hong Kong
Stockholms Universitet
University of Minnesota
Michael Antonov Foundation
Noaber Foundation
Insilico Medicine
Neye Foundation
Connor Fund
National Center for Advancing Translational Sciences UCLA Clinical and Translational Science Institute
Edythe Broad Center of Regenerative Medicine and Stem Cell Research
Max-Planck-Gesellschaft
Wenner-Gren Institute
Jonsson Cancer Center Foundation
National University Health System
USA 105Department of Molecular Biosciences
European Commission
VitaDao
Oppenheimer Program
University of Pittsburgh
Margaret E. Early Medical Research Trust
California Institute of Regenerative Medicine
Medicine Canada Inc.
Labs Inc.
Goethe-Universität Frankfurt am Main
European Research Council
National Institute on Aging
Centre for Physical Activity Research
Southern University of Science and Technology
National Eye Institute	R01AG063543, 1R43EY034403-01, U54AG076041, U54AG079754, ERC-2016-AdG-741966
TrygFonden	20045, 125132, ID 101390
Natural Science Foundation of Shandong Province	2021XDHZ082, ZR2023MH262
Irish Research Council	IRCLA/2017/58
Fondation Santé	19656
Lundbeck Foundation	R324-2019-1492
Science Foundation Ireland	19/FFP/6790
National Academy of Medicine	AG82764, AG68667
Max Planck Institute for Molecular Biomedicine, Münster, Germany 107Healthspan Capital	CA 94530
California Institute for Regenerative Medicine	-14096, ERC-2016AdG-741966
Tel Aviv University	CA 90001
National Institutes of Health	CA 94107, U01ES029519, P01AG017242, R01AG063404, R01AG 063389, R33AG061456, UG3CA268103, P01AG047200, U19AG056278, R01DK 117481, R01AG82708, R37AG013925, U01HL145560, R01AG068048, P01 AG062413, R01AG082105
Uddannelses- og Forskningsministeriet	0238-00003B
Wellcome Trust	220784/Z/20/Z
National University of Singapore	NUHSRO/2022/047/Startup/11
Indiana Clinical and Translational Sciences Institute	UL1TR000124
Novo Nordisk Foundation Challenge Programme	NNF17OC0027812
Nordea-fonden	02-2017-1749
University of California	CA 90095

Keywords

artificial intelligence
biotechnology
healthy longevity

Access to Document

10.18632/aging.206135

Cite this

Lyu, Y. X., Fu, Q., Wilczok, D., Ying, K., King, A., Antebi, A., Vojta, A., Stolzing, A., Moskalev, A., Georgievskaya, A., Maier, A. B., Olsen, A., Groth, A., Simon, A. K., Brunet, A., Jamil, A., Kulaga, A., Bhatti, A., Yaden, B., ... Bakula, D. (2024). Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging, 16(20), 12955-12976. https://doi.org/10.18632/aging.206135

@article{d4845aac90b94ebc9a21fb935a2ea599,

title = "Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity",

abstract = "The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.",

keywords = "artificial intelligence, biotechnology, healthy longevity",

author = "Lyu, \{Yu Xuan\} and Qiang Fu and Dominika Wilczok and Kejun Ying and Aaron King and Adam Antebi and Aleksandar Vojta and Alexandra Stolzing and Alexey Moskalev and Anastasia Georgievskaya and Maier, \{Andrea B.\} and Andrea Olsen and Anja Groth and Simon, \{Anna Katharina\} and Anne Brunet and Aisyah Jamil and Anton Kulaga and Asif Bhatti and Benjamin Yaden and Pedersen, \{Bente Klarlund\} and Bj{\"o}rn Schumacher and Boris Djordjevic and Brian Kennedy and Chieh Chen and Huang, \{Christine Yuan\} and Correll, \{Christoph U.\} and Murphy, \{Coleen T.\} and Ewald, \{Collin Y.\} and Danica Chen and Valenzano, \{Dario Riccardo\} and Dariusz So{\l}dacki and David Erritzoe and David Meyer and Sinclair, \{David A.\} and Chini, \{Eduardo Nunes\} and Teeling, \{Emma C.\} and Eric Morgen and Eric Verdin and Erik Vernet and Estefano Pinilla and Fang, \{Evandro F.\} and Evelyne Bischof and Mercken, \{Evi M.\} and Fabian Finger and Folkert Kuipers and Pun, \{Frank W.\} and Gabor Gy{\"u}lveszi and Gabriele Civiletto and Garri Zmudze and Gil Blander and Pincus, \{Harold A.\} and Joshua McClure and Kirkland, \{James L.\} and James Peyer and Justice, \{Jamie N.\} and Jan Vijg and Gruhn, \{Jennifer R.\} and Jerry McLaughlin and Joan Mannick and Jo{\~a}o Passos and Baur, \{Joseph A.\} and Joe Betts-LaCroix and Sedivy, \{John M.\} and Speakman, \{John R.\} and Jordan Shlain and \{von Maltzahn\}, Julia and Andreasson, \{Katrin I.\} and Kelsey Moody and Konstantinos Palikaras and Kristen Fortney and Niedernhofer, \{Laura J.\} and Rasmussen, \{Lene Juel\} and Veenhoff, \{Liesbeth M.\} and Lisa Melton and Luigi Ferrucci and Marco Quarta and Maria Koval and Maria Marinova and Mark Hamalainen and Maximilian Unfried and Ringel, \{Michael S.\} and Milos Filipovic and Mourad Topors and Natalia Mitin and Nawal Roy and Nika Pintar and Nir Barzilai and Paolo Binetti and Parminder Singh and Paul Kohlhaas and Robbins, \{Paul D.\} and Paul Rubin and Fedichev, \{Peter O.\} and Petrina Kamya and Pura Mu{\~n}oz-Canoves and Cabo, \{Rafael de\} and Faragher, \{Richard G.A.\} and Rob Konrad and Roberto Ripa and Robin Mansukhani and Sabrina B{\"u}ttner and Wickstr{\"o}m, \{Sara A.\} and Sebastian Brunemeier and Sergey Jakimov and Shan Luo and Sharon Rosenzweig-Lipson and Tsai, \{Shih Yin\} and Stefanie Dimmeler and Rando, \{Thomas A.\} and Peterson, \{Tim R.\} and Tina Woods and Tony Wyss-Coray and Toren Finkel and Tzipora Strauss and Gladyshev, \{Vadim N.\} and Longo, \{Valter D.\} and Dwaraka, \{Varun B.\} and Vera Gorbunova and Acosta-Rodr{\'i}guez, \{Victoria A.\} and Vincenzo Sorrentino and Vittorio Sebastiano and Wenbin Li and Yousin Suh and Alex Zhavoronkov and Morten Scheibye-Knudsen and Daniela Bakula",

note = "Publisher Copyright: {\textcopyright} 2024 Lyu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2024",

doi = "10.18632/aging.206135",

language = "אנגלית",

volume = "16",

pages = "12955--12976",

journal = "Aging",

issn = "1945-4589",

publisher = "Impact Journals LLC",

number = "20",

}

Lyu, YX, Fu, Q, Wilczok, D, Ying, K, King, A, Antebi, A, Vojta, A, Stolzing, A, Moskalev, A, Georgievskaya, A, Maier, AB, Olsen, A, Groth, A, Simon, AK, Brunet, A, Jamil, A, Kulaga, A, Bhatti, A, Yaden, B, Pedersen, BK, Schumacher, B, Djordjevic, B, Kennedy, B, Chen, C, Huang, CY, Correll, CU, Murphy, CT, Ewald, CY, Chen, D, Valenzano, DR, Sołdacki, D, Erritzoe, D, Meyer, D, Sinclair, DA, Chini, EN, Teeling, EC, Morgen, E, Verdin, E, Vernet, E, Pinilla, E, Fang, EF, Bischof, E, Mercken, EM, Finger, F, Kuipers, F, Pun, FW, Gyülveszi, G, Civiletto, G, Zmudze, G, Blander, G, Pincus, HA, McClure, J, Kirkland, JL, Peyer, J, Justice, JN, Vijg, J, Gruhn, JR, McLaughlin, J, Mannick, J, Passos, J, Baur, JA, Betts-LaCroix, J, Sedivy, JM, Speakman, JR, Shlain, J, von Maltzahn, J, Andreasson, KI, Moody, K, Palikaras, K, Fortney, K, Niedernhofer, LJ, Rasmussen, LJ, Veenhoff, LM, Melton, L, Ferrucci, L, Quarta, M, Koval, M, Marinova, M, Hamalainen, M, Unfried, M, Ringel, MS, Filipovic, M, Topors, M, Mitin, N, Roy, N, Pintar, N, Barzilai, N, Binetti, P, Singh, P, Kohlhaas, P, Robbins, PD, Rubin, P, Fedichev, PO, Kamya, P, Muñoz-Canoves, P, Cabo, RD, Faragher, RGA, Konrad, R, Ripa, R, Mansukhani, R, Büttner, S, Wickström, SA, Brunemeier, S, Jakimov, S, Luo, S, Rosenzweig-Lipson, S, Tsai, SY, Dimmeler, S, Rando, TA, Peterson, TR, Woods, T, Wyss-Coray, T, Finkel, T, Strauss, T, Gladyshev, VN, Longo, VD, Dwaraka, VB, Gorbunova, V, Acosta-Rodríguez, VA, Sorrentino, V, Sebastiano, V, Li, W, Suh, Y, Zhavoronkov, A, Scheibye-Knudsen, M & Bakula, D 2024, 'Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity', Aging, vol. 16, no. 20, pp. 12955-12976. https://doi.org/10.18632/aging.206135

TY - JOUR

T1 - Longevity biotechnology

T2 - bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

AU - Lyu, Yu Xuan

AU - Fu, Qiang

AU - Wilczok, Dominika

AU - Ying, Kejun

AU - King, Aaron

AU - Antebi, Adam

AU - Vojta, Aleksandar

AU - Stolzing, Alexandra

AU - Moskalev, Alexey

AU - Georgievskaya, Anastasia

AU - Maier, Andrea B.

AU - Olsen, Andrea

AU - Groth, Anja

AU - Simon, Anna Katharina

AU - Brunet, Anne

AU - Jamil, Aisyah

AU - Kulaga, Anton

AU - Bhatti, Asif

AU - Yaden, Benjamin

AU - Pedersen, Bente Klarlund

AU - Schumacher, Björn

AU - Djordjevic, Boris

AU - Kennedy, Brian

AU - Chen, Chieh

AU - Huang, Christine Yuan

AU - Correll, Christoph U.

AU - Murphy, Coleen T.

AU - Ewald, Collin Y.

AU - Chen, Danica

AU - Valenzano, Dario Riccardo

AU - Sołdacki, Dariusz

AU - Erritzoe, David

AU - Meyer, David

AU - Sinclair, David A.

AU - Chini, Eduardo Nunes

AU - Teeling, Emma C.

AU - Morgen, Eric

AU - Verdin, Eric

AU - Vernet, Erik

AU - Pinilla, Estefano

AU - Fang, Evandro F.

AU - Bischof, Evelyne

AU - Mercken, Evi M.

AU - Finger, Fabian

AU - Kuipers, Folkert

AU - Pun, Frank W.

AU - Gyülveszi, Gabor

AU - Civiletto, Gabriele

AU - Zmudze, Garri

AU - Blander, Gil

AU - Pincus, Harold A.

AU - McClure, Joshua

AU - Kirkland, James L.

AU - Peyer, James

AU - Justice, Jamie N.

AU - Vijg, Jan

AU - Gruhn, Jennifer R.

AU - McLaughlin, Jerry

AU - Mannick, Joan

AU - Passos, João

AU - Baur, Joseph A.

AU - Betts-LaCroix, Joe

AU - Sedivy, John M.

AU - Speakman, John R.

AU - Shlain, Jordan

AU - von Maltzahn, Julia

AU - Andreasson, Katrin I.

AU - Moody, Kelsey

AU - Palikaras, Konstantinos

AU - Fortney, Kristen

AU - Niedernhofer, Laura J.

AU - Rasmussen, Lene Juel

AU - Veenhoff, Liesbeth M.

AU - Melton, Lisa

AU - Ferrucci, Luigi

AU - Quarta, Marco

AU - Koval, Maria

AU - Marinova, Maria

AU - Hamalainen, Mark

AU - Unfried, Maximilian

AU - Ringel, Michael S.

AU - Filipovic, Milos

AU - Topors, Mourad

AU - Mitin, Natalia

AU - Roy, Nawal

AU - Pintar, Nika

AU - Barzilai, Nir

AU - Binetti, Paolo

AU - Singh, Parminder

AU - Kohlhaas, Paul

AU - Robbins, Paul D.

AU - Rubin, Paul

AU - Fedichev, Peter O.

AU - Kamya, Petrina

AU - Muñoz-Canoves, Pura

AU - Cabo, Rafael de

AU - Faragher, Richard G.A.

AU - Konrad, Rob

AU - Ripa, Roberto

AU - Mansukhani, Robin

AU - Büttner, Sabrina

AU - Wickström, Sara A.

AU - Brunemeier, Sebastian

AU - Jakimov, Sergey

AU - Luo, Shan

AU - Rosenzweig-Lipson, Sharon

AU - Tsai, Shih Yin

AU - Dimmeler, Stefanie

AU - Rando, Thomas A.

AU - Peterson, Tim R.

AU - Woods, Tina

AU - Wyss-Coray, Tony

AU - Finkel, Toren

AU - Strauss, Tzipora

AU - Gladyshev, Vadim N.

AU - Longo, Valter D.

AU - Dwaraka, Varun B.

AU - Gorbunova, Vera

AU - Acosta-Rodríguez, Victoria A.

AU - Sorrentino, Vincenzo

AU - Sebastiano, Vittorio

AU - Li, Wenbin

AU - Suh, Yousin

AU - Zhavoronkov, Alex

AU - Scheibye-Knudsen, Morten

AU - Bakula, Daniela

N1 - Publisher Copyright: © 2024 Lyu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2024

Y1 - 2024

N2 - The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

AB - The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

KW - artificial intelligence

KW - biotechnology

KW - healthy longevity

UR - https://www.scopus.com/pages/publications/85208049247

U2 - 10.18632/aging.206135

DO - 10.18632/aging.206135

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 39418098

AN - SCOPUS:85208049247

SN - 1945-4589

VL - 16

SP - 12955

EP - 12976

JO - Aging

JF - Aging

IS - 20

ER -

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

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