TY - JOUR
T1 - Longer-acting treatments for neovascular age-related macular degeneration—present and future
AU - Iglicki, Matias
AU - González, David Pérez
AU - Loewenstein, Anat
AU - Zur, Dinah
N1 - Publisher Copyright:
© 2020, The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
PY - 2021/4
Y1 - 2021/4
N2 - The treatment of neovascular AMD (nAMD) has been revolutionized by the introduction of anti-vascular endothelial growth factor (VEGF) agents. Though, there is a tremendous gap between the outcomes in randomized clinical trials and real-world settings, where long-term outcomes are not as good as expected. This is due to undertreatment, i.e., fewer injection and low monitoring frequency. Treatment burden due to frequent injections remains a major limitation. Long-lasting treatments provide promising solutions for this unmet need by achieving better results with less mandatory injections. This review aims to cover the current state in this field and also discuss the mechanism of action, data from pivotal trials, and safety profile of long-acting treatments in present and future, going into details about the following agents: Brolucizumab, Faricimab, Abipicar, and Conbercept.
AB - The treatment of neovascular AMD (nAMD) has been revolutionized by the introduction of anti-vascular endothelial growth factor (VEGF) agents. Though, there is a tremendous gap between the outcomes in randomized clinical trials and real-world settings, where long-term outcomes are not as good as expected. This is due to undertreatment, i.e., fewer injection and low monitoring frequency. Treatment burden due to frequent injections remains a major limitation. Long-lasting treatments provide promising solutions for this unmet need by achieving better results with less mandatory injections. This review aims to cover the current state in this field and also discuss the mechanism of action, data from pivotal trials, and safety profile of long-acting treatments in present and future, going into details about the following agents: Brolucizumab, Faricimab, Abipicar, and Conbercept.
UR - http://www.scopus.com/inward/record.url?scp=85100140178&partnerID=8YFLogxK
U2 - 10.1038/s41433-020-01309-9
DO - 10.1038/s41433-020-01309-9
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C2 - 33432165
AN - SCOPUS:85100140178
SN - 0950-222X
VL - 35
SP - 1111
EP - 1116
JO - Eye
JF - Eye
IS - 4
ER -