The effect of long-term verapamil treatment on [3H]imipramine binding to the serotonin transporter in human platelets was studied. A significant increase (24%, P<0.05) in the density of high-affinity imipramine binding sites was observed in platelets of cardiac patients maintained exclusively on verapamil. The up-regulation of the serotonin transporter may be relevant to the previously reported beneficial effect of verapamil in affective disorders.
- 5-HT transporter
- Imipramine binding