Long-term verapamil treatment increases [3H]imipramine binding in human platelets

Adi Cohen; Abraham Weizman; Michael Eldar; Moshe Rehavi

doi:10.1016/0014-2999(90)90096-O

Long-term verapamil treatment increases [³H]imipramine binding in human platelets

Adi Cohen, Abraham Weizman, Michael Eldar, Moshe Rehavi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of long-term verapamil treatment on [³H]imipramine binding to the serotonin transporter in human platelets was studied. A significant increase (24%, P<0.05) in the density of high-affinity imipramine binding sites was observed in platelets of cardiac patients maintained exclusively on verapamil. The up-regulation of the serotonin transporter may be relevant to the previously reported beneficial effect of verapamil in affective disorders.

Original language	English
Pages (from-to)	311-314
Number of pages	4
Journal	European Journal of Pharmacology
Volume	181
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(90)90096-O
State	Published - 8 Jun 1990

Keywords

5-HT transporter
Imipramine binding
Platelets
Verapamil

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10.1016/0014-2999(90)90096-O

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title = "Long-term verapamil treatment increases [3H]imipramine binding in human platelets",

abstract = "The effect of long-term verapamil treatment on [3H]imipramine binding to the serotonin transporter in human platelets was studied. A significant increase (24%, P<0.05) in the density of high-affinity imipramine binding sites was observed in platelets of cardiac patients maintained exclusively on verapamil. The up-regulation of the serotonin transporter may be relevant to the previously reported beneficial effect of verapamil in affective disorders.",

keywords = "5-HT transporter, Imipramine binding, Platelets, Verapamil",

author = "Adi Cohen and Abraham Weizman and Michael Eldar and Moshe Rehavi",

note = "Funding Information: This research was supported by the Basic Research Foundation administered by the Israeli Academy of Sciences and Humanities and by the Chief Scientist of the Israeli Ministry of Health.",

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doi = "10.1016/0014-2999(90)90096-O",

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AU - Cohen, Adi

AU - Weizman, Abraham

AU - Eldar, Michael

AU - Rehavi, Moshe

N1 - Funding Information: This research was supported by the Basic Research Foundation administered by the Israeli Academy of Sciences and Humanities and by the Chief Scientist of the Israeli Ministry of Health.

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AB - The effect of long-term verapamil treatment on [3H]imipramine binding to the serotonin transporter in human platelets was studied. A significant increase (24%, P<0.05) in the density of high-affinity imipramine binding sites was observed in platelets of cardiac patients maintained exclusively on verapamil. The up-regulation of the serotonin transporter may be relevant to the previously reported beneficial effect of verapamil in affective disorders.

KW - 5-HT transporter

KW - Imipramine binding

KW - Platelets

KW - Verapamil

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JO - European Journal of Pharmacology

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Long-term verapamil treatment increases [³H]imipramine binding in human platelets

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