Long-term verapamil treatment increases [3H]imipramine binding in human platelets

Adi Cohen, Abraham Weizman, Michael Eldar, Moshe Rehavi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effect of long-term verapamil treatment on [3H]imipramine binding to the serotonin transporter in human platelets was studied. A significant increase (24%, P<0.05) in the density of high-affinity imipramine binding sites was observed in platelets of cardiac patients maintained exclusively on verapamil. The up-regulation of the serotonin transporter may be relevant to the previously reported beneficial effect of verapamil in affective disorders.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number3
StatePublished - 8 Jun 1990


  • 5-HT transporter
  • Imipramine binding
  • Platelets
  • Verapamil


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