Abstract
The effect of long-term verapamil treatment on [3H]imipramine binding to the serotonin transporter in human platelets was studied. A significant increase (24%, P<0.05) in the density of high-affinity imipramine binding sites was observed in platelets of cardiac patients maintained exclusively on verapamil. The up-regulation of the serotonin transporter may be relevant to the previously reported beneficial effect of verapamil in affective disorders.
Original language | English |
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Pages (from-to) | 311-314 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 181 |
Issue number | 3 |
DOIs | |
State | Published - 8 Jun 1990 |
Keywords
- 5-HT transporter
- Imipramine binding
- Platelets
- Verapamil