TY - JOUR
T1 - Long-term variability in glycemic control is associated with white matter hyperintensities in APOE4 genotype carriers with type 2 diabetes
AU - Livny, Abigail
AU - Ravona-Springer, Ramit
AU - Heymann, Anthony
AU - Priess, Rachel
AU - Kushnir, Tammar
AU - Tsarfaty, Galia
AU - Rabinov, Leeron
AU - Moran, Reut
AU - Hoffman, Hadass
AU - Cooper, Itzik
AU - Greenbaum, Lior
AU - Silverman, Jeremy
AU - Sano, Mary
AU - Johnson, Sterling C.
AU - Bendlin, Barbara B.
AU - Beeri, Michal Schnaider
N1 - Publisher Copyright:
© 2016 by the American Diabetes Association.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - OBJECTIVE We assessed whether the apolipoprotein ϵ4 (APOE4) genotype affects the relationship of variability in long-term glycemic control (measured by HbA1c SD of multiple measurements) with white matter hyperintensities (WMHs) in elderly patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS WMH volume was generated from structural T1 and fluid-attenuated inversion recovery MRI in each subject. The analysis included 124 subjects; 27 (21.8%) had one or more APOE4 alleles. RESULTS HbA1c variability was associated with significantly higher WMH in APOE4 carriers (r 5 0.47, P 5 0.03), controlling for age, sex, mean HbA1c , number of follow-up years, and a composite of cardiovascular risk factors, but not in noncarriers (r 5 20.04, P 5 0.71; P for interaction 5 0.050). CONCLUSIONS The results suggest that the APOE4 genotype affects the relationship of long-term glycemic control with WMH load so that APOE4 carriers may be more vulnerable to the insults of poor control.
AB - OBJECTIVE We assessed whether the apolipoprotein ϵ4 (APOE4) genotype affects the relationship of variability in long-term glycemic control (measured by HbA1c SD of multiple measurements) with white matter hyperintensities (WMHs) in elderly patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS WMH volume was generated from structural T1 and fluid-attenuated inversion recovery MRI in each subject. The analysis included 124 subjects; 27 (21.8%) had one or more APOE4 alleles. RESULTS HbA1c variability was associated with significantly higher WMH in APOE4 carriers (r 5 0.47, P 5 0.03), controlling for age, sex, mean HbA1c , number of follow-up years, and a composite of cardiovascular risk factors, but not in noncarriers (r 5 20.04, P 5 0.71; P for interaction 5 0.050). CONCLUSIONS The results suggest that the APOE4 genotype affects the relationship of long-term glycemic control with WMH load so that APOE4 carriers may be more vulnerable to the insults of poor control.
UR - https://www.scopus.com/pages/publications/84971265349
U2 - 10.2337/dc15-2331
DO - 10.2337/dc15-2331
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AN - SCOPUS:84971265349
SN - 0149-5992
VL - 39
SP - 1056
EP - 1059
JO - Diabetes Care
JF - Diabetes Care
IS - 6
ER -
