TY - JOUR
T1 - Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk
AU - West, Rebecca K.
AU - Ravona-Springer, Ramit
AU - Sharvit-Ginon, Inbal
AU - Ganmore, Ithamar
AU - Manzali, Sigalit
AU - Tirosh, Amir
AU - Golan, Sapir
AU - Boccara, Ethel
AU - Heymann, Anthony
AU - Beeri, Michal Schnaider
N1 - Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association
PY - 2021
Y1 - 2021
N2 - Introduction: We examined relationships of body mass index (BMI) with cognition in middle-aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods: Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long-term trajectories of BMI with cognition. Results: Higher BMI was associated with worse language (P =.045). Interactions of BMI with parental history were significant for episodic memory (P =.023), language (p =.027), working memory (P =.006), global cognition (P =.008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P =.017), language (P =.013), working memory (P =.001), global cognition (P =.005), with stronger associations for maternal history. Discussion: Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.
AB - Introduction: We examined relationships of body mass index (BMI) with cognition in middle-aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods: Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long-term trajectories of BMI with cognition. Results: Higher BMI was associated with worse language (P =.045). Interactions of BMI with parental history were significant for episodic memory (P =.023), language (p =.027), working memory (P =.006), global cognition (P =.008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P =.017), language (P =.013), working memory (P =.001), global cognition (P =.005), with stronger associations for maternal history. Discussion: Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.
KW - Alzheimer's disease
KW - adiposity
KW - cognition
KW - cognitive decline
KW - obesity
KW - parental history of Alzheimer's disease
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85124409710&partnerID=8YFLogxK
U2 - 10.1002/dad2.12247
DO - 10.1002/dad2.12247
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C2 - 35005193
AN - SCOPUS:85124409710
SN - 2352-8729
VL - 13
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 1
M1 - e12247
ER -
