Long-term clinical and metabolic results of subtotal gastrectomy for duodenal ulcer in 133 patients are reported. The operative procedure consisted of a 4/5 gastric resection with a retrocolic no-loop Hoffmeister anastomosis. After detailed clinical and metabolic assessment, 84% of the patients were graded Visick grades I and II. Postgastrectomy symptoms were few, only mild or moderate in intensity, and were not disabling in any of the cases. No diarrhea or vomiting was noted. Weight loss was observed in 16% of the patients, 14% losing less than 5 kg. Diarrhea or malabsorption was not encountered in the entire series. The incidence of anemia was 5.5%. None of the hemoglobin levels were below 10.5 g/dl. All cases of anemia were microcytic, hypochromic, iron deficient. There were no hematological or clinical signs suggestive of macrocytic anemia in the entire series. Plasma protein, calcium, and phosphorus levels were within normal limits. All patients were free of clinical complaints and history suggestive of bone disease. It is believed that the low morbidity and the few and mild metabolic sequelae are due to the type of anastomosis used.