Long-term remission of disseminated parathyroid cancer following immunotherapy

Marta Sarquis; Stephen J. Marx; Albert Beckers; Arthur R. Bradwell; William F. Simonds; Maria Aparecida C. Bicalho; Adrian F. Daly; Daniela Betea; Eitan Friedman; Luiz De Marco

doi:10.1007/s12020-019-02136-z

Long-term remission of disseminated parathyroid cancer following immunotherapy

Marta Sarquis, Stephen J. Marx, Albert Beckers, Arthur R. Bradwell, William F. Simonds, Maria Aparecida C. Bicalho, Adrian F. Daly, Daniela Betea, Eitan Friedman, Luiz De Marco^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Purpose: Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered. Subject and results: A patient with CDC73-associated metastatic parathyroid carcinoma was treated with combined anti-hPTH immunotherapy and surgery. Conclusions: Following five courses of anti-hPTH immunotherapy and subsequent surgery, a 12-year long remission of disseminated parathyroid cancer is reported. This case further supports the ever-expanding spectrum of cancers that may benefit from immunotherapy.

Original language	English
Pages (from-to)	204-208
Number of pages	5
Journal	Endocrine
Volume	67
Issue number	1
DOIs	https://doi.org/10.1007/s12020-019-02136-z
State	Published - 1 Jan 2020
Externally published	Yes

Funding

Funders	Funder number
National Institutes of Health	F05TW002013
National Institute of Diabetes and Digestive and Kidney Diseases	ZIADK043012
NIH Clinical Center
Conselho Nacional de Desenvolvimento Científico e Tecnológico	405053/2013-4

Keywords

Cancer
Immunotherapy
Parathyroid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12020-019-02136-z

Cite this

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title = "Long-term remission of disseminated parathyroid cancer following immunotherapy",

abstract = "Purpose: Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered. Subject and results: A patient with CDC73-associated metastatic parathyroid carcinoma was treated with combined anti-hPTH immunotherapy and surgery. Conclusions: Following five courses of anti-hPTH immunotherapy and subsequent surgery, a 12-year long remission of disseminated parathyroid cancer is reported. This case further supports the ever-expanding spectrum of cancers that may benefit from immunotherapy.",

keywords = "Cancer, Immunotherapy, Parathyroid",

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doi = "10.1007/s12020-019-02136-z",

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T1 - Long-term remission of disseminated parathyroid cancer following immunotherapy

AU - Sarquis, Marta

AU - Marx, Stephen J.

AU - Beckers, Albert

AU - Bradwell, Arthur R.

AU - Simonds, William F.

AU - Bicalho, Maria Aparecida C.

AU - Daly, Adrian F.

AU - Betea, Daniela

AU - Friedman, Eitan

AU - De Marco, Luiz

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Purpose: Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered. Subject and results: A patient with CDC73-associated metastatic parathyroid carcinoma was treated with combined anti-hPTH immunotherapy and surgery. Conclusions: Following five courses of anti-hPTH immunotherapy and subsequent surgery, a 12-year long remission of disseminated parathyroid cancer is reported. This case further supports the ever-expanding spectrum of cancers that may benefit from immunotherapy.

AB - Purpose: Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered. Subject and results: A patient with CDC73-associated metastatic parathyroid carcinoma was treated with combined anti-hPTH immunotherapy and surgery. Conclusions: Following five courses of anti-hPTH immunotherapy and subsequent surgery, a 12-year long remission of disseminated parathyroid cancer is reported. This case further supports the ever-expanding spectrum of cancers that may benefit from immunotherapy.

KW - Cancer

KW - Immunotherapy

KW - Parathyroid

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Long-term remission of disseminated parathyroid cancer following immunotherapy

Abstract

Funding

Keywords

UN SDGs

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