TY - JOUR
T1 - Long-term ovarian reserve and fertility outcomes in female survivors of childhood acute lymphoblastic leukemia
AU - Elitzur, Sarah
AU - Frank, Shani
AU - Goshen-Lago, Tal
AU - Barzilai-Birenboim, Shlomit
AU - Gilad, Gil
AU - Avrahami, Galia
AU - Goldberg, Tracie
AU - Litichever, Naomi
AU - Masarwa, Ameena
AU - Oron, Galia
AU - Yaniv, Isaac
AU - Izraeli, Shai
AU - Ben-Aharon, Irit
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, yet data regarding long-term ovarian reserve of female survivors are limited. The aim of this study was to investigate whether there is a differential pattern of anti-Mullerian hormone (AMH) levels in female childhood ALL survivors compared with the normal age-matched population. In a cohort of 56 female childhood ALL survivors (median age 29 years; median follow-up 20.6 years), a negative correlation was found between age at leukemia diagnosis and age-adjusted anti-Mullerian hormone (AMH) levels (r = −0.334, p =.031). Despite alkylating agent therapy, AMH levels did not differ significantly from age-related nomograms (age < 30, p =.17; age ≥ 30, p =.94). The mean number of children per fertile woman adjusted for maternal age was similar to the national average (2.76 versus 3.11, p =.19). Our results imply that reproductive outcomes are not significantly hampered in female pediatric ALL survivors. Long-term surveillance of ovarian reserve may enable personalized survivorship counseling.
AB - Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, yet data regarding long-term ovarian reserve of female survivors are limited. The aim of this study was to investigate whether there is a differential pattern of anti-Mullerian hormone (AMH) levels in female childhood ALL survivors compared with the normal age-matched population. In a cohort of 56 female childhood ALL survivors (median age 29 years; median follow-up 20.6 years), a negative correlation was found between age at leukemia diagnosis and age-adjusted anti-Mullerian hormone (AMH) levels (r = −0.334, p =.031). Despite alkylating agent therapy, AMH levels did not differ significantly from age-related nomograms (age < 30, p =.17; age ≥ 30, p =.94). The mean number of children per fertile woman adjusted for maternal age was similar to the national average (2.76 versus 3.11, p =.19). Our results imply that reproductive outcomes are not significantly hampered in female pediatric ALL survivors. Long-term surveillance of ovarian reserve may enable personalized survivorship counseling.
KW - Acute lymphoblastic leukemia (ALL)
KW - anti-Mullerian hormone (AMH)
KW - children
KW - fertility
KW - ovarian reserve
UR - http://www.scopus.com/inward/record.url?scp=85102947836&partnerID=8YFLogxK
U2 - 10.1080/10428194.2021.1901093
DO - 10.1080/10428194.2021.1901093
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C2 - 33749493
AN - SCOPUS:85102947836
SN - 1042-8194
VL - 62
SP - 2211
EP - 2218
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 9
ER -