Long-term ophthalmological follow-up of children with parinaud syndrome

Nitza Goldenberg-Cohen*, Jordana Haber, Yonina Ron, Liora Kornreich, Helen Toledano, Moshe Snir, Ian J. Cohen, Shalom Michowiz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


■ BACKGROUND AND OBJECTIVE: To assess the long-term ophthalmological outcome of Parinaud syndrome. ■ PATIENTS AND METHODS: The files of 6 children with tumor-related Parinaud syndrome diagnosed and observed from 2000 to 2007 were reviewed. All had papilledema indicating increased intracranial pressure. ■ RESULTS: Mean presentation-to-diagnosis delay was 3.6 weeks. Treatment consisted of surgical shunting and complete or partial resection with adjuvant chemotherapy (n = 4) and radiation (n = 3). Visual acuity remained stable or improved in 8 of 9 eyes with 20/30 visual acuity at diagnosis; improved bilaterally in 1 patient from 20/100 to 20/25; and deteriorated bilaterally in 1 patient from 20/30 and 20/200 to counting fingers and hand motions, respectively. The most improvement was achieved within 4 months. Findings at follow-up (mean: 4.2 years) included up gaze limitation (minimal in 2 patients), abnormal convergence, convergence retraction nystagmus, and light-near dissociation. One child had bilateral optic atrophy. ■ CONCLUSION: Children with tumor-related Parinaud syndrome tend to have subtle but measurable residual ophthalmological findings years after diagnosis and treatment.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalOphthalmic Surgery Lasers and Imaging
Issue number4
StatePublished - Jul 2010


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