Long-term memory requires polyADP-ribosylation

Malka Cohen-Armon; Leonid Visochek; Ayelet Katzoff; David Levitan; Abraham J. Susswein; Rodika Klein; Mireille Valbrun; James H. Schwartz

doi:10.1126/science.1096775

Long-term memory requires polyADP-ribosylation

Malka Cohen-Armon^*, Leonid Visochek, Ayelet Katzoff, David Levitan, Abraham J. Susswein, Rodika Klein, Mireille Valbrun, James H. Schwartz

^*Corresponding author for this work

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Abstract

PolyADP-ribose-polymerase 1 is activated in neurons that mediate several forms of long-term memory in Aplysia. Because polyADP-ribosylation of nuclear proteins is a response to DNA damage in virtually all eukaryotic cells, it is surprising that activation of the polymerase occurs during learning and is required for long-term memory. We suggest that fast and transient decondensation of chromatin structure by polyADP-ribosytation enables the transcription needed to form long-term memory without strand breaks in DNA.

Original language	English
Pages (from-to)	1820-1822
Number of pages	3
Journal	Science
Volume	304
Issue number	5678
DOIs	https://doi.org/10.1126/science.1096775
State	Published - 18 Jun 2004

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AU - Cohen-Armon, Malka

AU - Visochek, Leonid

AU - Katzoff, Ayelet

AU - Levitan, David

AU - Susswein, Abraham J.

AU - Klein, Rodika

AU - Valbrun, Mireille

AU - Schwartz, James H.

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AB - PolyADP-ribose-polymerase 1 is activated in neurons that mediate several forms of long-term memory in Aplysia. Because polyADP-ribosylation of nuclear proteins is a response to DNA damage in virtually all eukaryotic cells, it is surprising that activation of the polymerase occurs during learning and is required for long-term memory. We suggest that fast and transient decondensation of chromatin structure by polyADP-ribosytation enables the transcription needed to form long-term memory without strand breaks in DNA.

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Long-term memory requires polyADP-ribosylation

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