Long-term memory requires polyADP-ribosylation

Malka Cohen-Armon*, Leonid Visochek, Ayelet Katzoff, David Levitan, Abraham J. Susswein, Rodika Klein, Mireille Valbrun, James H. Schwartz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


PolyADP-ribose-polymerase 1 is activated in neurons that mediate several forms of long-term memory in Aplysia. Because polyADP-ribosylation of nuclear proteins is a response to DNA damage in virtually all eukaryotic cells, it is surprising that activation of the polymerase occurs during learning and is required for long-term memory. We suggest that fast and transient decondensation of chromatin structure by polyADP-ribosytation enables the transcription needed to form long-term memory without strand breaks in DNA.

Original languageEnglish
Pages (from-to)1820-1822
Number of pages3
Issue number5678
StatePublished - 18 Jun 2004


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