Long-term interactions between endogenous and exogenous opiates

Yosef Sarne, Yehoshua Gothilf, Ben Avi Weissman

Research output: Contribution to journalArticlepeer-review

Abstract

The in vitro biological effect of various opiates was studied in the guinea pig ileum bioassay. Besides their direct, immediate effect, certain opiates induced sensitivity changes whichpersisted after their removal and the complete recovery of the preparation. These specific, asymmetrical interactions may represent long-term modulation of the opiate receptor. The in vivo pharmacological implication of opiate interaction is discussed.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalEuropean Journal of Pharmacology
Volume62
Issue number1
DOIs
StatePublished - 7 Mar 1980

Keywords

  • Drug interaction
  • Endorphin
  • Enkephalin
  • Morphine
  • opiates

Fingerprint

Dive into the research topics of 'Long-term interactions between endogenous and exogenous opiates'. Together they form a unique fingerprint.

Cite this