Long-term interactions between endogenous and exogenous opiates

Yosef Sarne; Yehoshua Gothilf; Ben Avi Weissman

doi:10.1016/0014-2999(80)90488-4

Long-term interactions between endogenous and exogenous opiates

Yosef Sarne^*, Yehoshua Gothilf, Ben Avi Weissman

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

The in vitro biological effect of various opiates was studied in the guinea pig ileum bioassay. Besides their direct, immediate effect, certain opiates induced sensitivity changes whichpersisted after their removal and the complete recovery of the preparation. These specific, asymmetrical interactions may represent long-term modulation of the opiate receptor. The in vivo pharmacological implication of opiate interaction is discussed.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	European Journal of Pharmacology
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(80)90488-4
State	Published - 7 Mar 1980

Keywords

Drug interaction
Endorphin
Enkephalin
Morphine
opiates

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10.1016/0014-2999(80)90488-4

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abstract = "The in vitro biological effect of various opiates was studied in the guinea pig ileum bioassay. Besides their direct, immediate effect, certain opiates induced sensitivity changes whichpersisted after their removal and the complete recovery of the preparation. These specific, asymmetrical interactions may represent long-term modulation of the opiate receptor. The in vivo pharmacological implication of opiate interaction is discussed.",

keywords = "Drug interaction, Endorphin, Enkephalin, Morphine, opiates",

author = "Yosef Sarne and Yehoshua Gothilf and Weissman, {Ben Avi}",

note = "Funding Information: This study was supported by the Israel Center for Psychobiology, The Charles Smith Foundation Grant 17/79 to Y.S.",

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AB - The in vitro biological effect of various opiates was studied in the guinea pig ileum bioassay. Besides their direct, immediate effect, certain opiates induced sensitivity changes whichpersisted after their removal and the complete recovery of the preparation. These specific, asymmetrical interactions may represent long-term modulation of the opiate receptor. The in vivo pharmacological implication of opiate interaction is discussed.

KW - Drug interaction

KW - Endorphin

KW - Enkephalin

KW - Morphine

KW - opiates

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Long-term interactions between endogenous and exogenous opiates

Abstract

Keywords

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