The in vitro biological effect of various opiates was studied in the guinea pig ileum bioassay. Besides their direct, immediate effect, certain opiates induced sensitivity changes whichpersisted after their removal and the complete recovery of the preparation. These specific, asymmetrical interactions may represent long-term modulation of the opiate receptor. The in vivo pharmacological implication of opiate interaction is discussed.
|Number of pages||4|
|Journal||European Journal of Pharmacology|
|State||Published - 7 Mar 1980|
- Drug interaction