Long-term interactions between endogenous and exogenous opiates

Yosef Sarne*, Yehoshua Gothilf, Ben Avi Weissman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The in vitro biological effect of various opiates was studied in the guinea pig ileum bioassay. Besides their direct, immediate effect, certain opiates induced sensitivity changes whichpersisted after their removal and the complete recovery of the preparation. These specific, asymmetrical interactions may represent long-term modulation of the opiate receptor. The in vivo pharmacological implication of opiate interaction is discussed.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number1
StatePublished - 7 Mar 1980


FundersFunder number
Charles Smith Foundation17/79
Israel Center for Psychobiology


    • Drug interaction
    • Endorphin
    • Enkephalin
    • Morphine
    • opiates


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