Long-term immunity in young adults after a single dose of inactivated Hepatitis A vaccines

Nadav Orr; Eyal Klement; David Gillis; Tamar Sela; Raid Kayouf; Estela Derazne; Itamar Grotto; Ran Balicer; Michael Huerta; Lisa Aviram; Ruhama Ambar; Yoram Epstein; Yuval Heled; Dani Cohen

doi:10.1016/j.vaccine.2006.03.010

Long-term immunity in young adults after a single dose of inactivated Hepatitis A vaccines

Nadav Orr^*, Eyal Klement, David Gillis, Tamar Sela, Raid Kayouf, Estela Derazne, Itamar Grotto, Ran Balicer, Michael Huerta, Lisa Aviram, Ruhama Ambar, Yoram Epstein, Yuval Heled, Dani Cohen

^*Corresponding author for this work

School of Public Health

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We evaluated in a prospective study the immune response of naïve subjects to a single dose of inactivated Hepatitis A vaccine. Ninety-seven percent of the vaccinees sero-converted 1 month after vaccination and 93% were still positive 2 years later. All of the vaccinees had a strong booster response 2 years after the single dose. Avaxim was more immunogenic than Vaqta for the primary dose (p = 0.01 for sero-positivity, p < 0.001 for antibody level) but no differences were found after boosting with Avaxim. Performance of intense physical activity during the first month after a single vaccine dose was associated with lower antibody levels (p = 0.004). This study indicates that a single dose of inactivated HAV vaccine elicits protective immune memory for at least 2 years.

Original language	English
Pages (from-to)	4328-4332
Number of pages	5
Journal	Vaccine
Volume	24
Issue number	20
DOIs	https://doi.org/10.1016/j.vaccine.2006.03.010
State	Published - 15 May 2006

Keywords

Hepatitis A vaccine
Long term protection
Single dose

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2006.03.010

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title = "Long-term immunity in young adults after a single dose of inactivated Hepatitis A vaccines",

abstract = "We evaluated in a prospective study the immune response of na{\"i}ve subjects to a single dose of inactivated Hepatitis A vaccine. Ninety-seven percent of the vaccinees sero-converted 1 month after vaccination and 93% were still positive 2 years later. All of the vaccinees had a strong booster response 2 years after the single dose. Avaxim was more immunogenic than Vaqta for the primary dose (p = 0.01 for sero-positivity, p < 0.001 for antibody level) but no differences were found after boosting with Avaxim. Performance of intense physical activity during the first month after a single vaccine dose was associated with lower antibody levels (p = 0.004). This study indicates that a single dose of inactivated HAV vaccine elicits protective immune memory for at least 2 years.",

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AU - Orr, Nadav

AU - Klement, Eyal

AU - Gillis, David

AU - Sela, Tamar

AU - Kayouf, Raid

AU - Derazne, Estela

AU - Grotto, Itamar

AU - Balicer, Ran

AU - Huerta, Michael

AU - Aviram, Lisa

AU - Ambar, Ruhama

AU - Epstein, Yoram

AU - Heled, Yuval

AU - Cohen, Dani

PY - 2006/5/15

Y1 - 2006/5/15

N2 - We evaluated in a prospective study the immune response of naïve subjects to a single dose of inactivated Hepatitis A vaccine. Ninety-seven percent of the vaccinees sero-converted 1 month after vaccination and 93% were still positive 2 years later. All of the vaccinees had a strong booster response 2 years after the single dose. Avaxim was more immunogenic than Vaqta for the primary dose (p = 0.01 for sero-positivity, p < 0.001 for antibody level) but no differences were found after boosting with Avaxim. Performance of intense physical activity during the first month after a single vaccine dose was associated with lower antibody levels (p = 0.004). This study indicates that a single dose of inactivated HAV vaccine elicits protective immune memory for at least 2 years.

AB - We evaluated in a prospective study the immune response of naïve subjects to a single dose of inactivated Hepatitis A vaccine. Ninety-seven percent of the vaccinees sero-converted 1 month after vaccination and 93% were still positive 2 years later. All of the vaccinees had a strong booster response 2 years after the single dose. Avaxim was more immunogenic than Vaqta for the primary dose (p = 0.01 for sero-positivity, p < 0.001 for antibody level) but no differences were found after boosting with Avaxim. Performance of intense physical activity during the first month after a single vaccine dose was associated with lower antibody levels (p = 0.004). This study indicates that a single dose of inactivated HAV vaccine elicits protective immune memory for at least 2 years.

KW - Hepatitis A vaccine

KW - Long term protection

KW - Single dose

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SN - 0264-410X

VL - 24

SP - 4328

EP - 4332

JO - Vaccine

JF - Vaccine

IS - 20

ER -

Long-term immunity in young adults after a single dose of inactivated Hepatitis A vaccines

Abstract

Keywords

UN SDGs

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