Long-term follow-up on fetuses with isolated sonographic finding of short long bones: a cohort study

Aya Mohr-Sasson, Shlomi Toussia-Cohen, Moran Shapira, Sharon Perlman, Reuven Achiron, Yinon Gilboa

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate the long-term outcome of fetuses with a diagnosis of isolated short long bones. Methods: A retrospective review was conducted of all cases diagnosed with short long bones above 20 weeks of gestation during 2010–2017 in a single tertiary center. Exclusion criteria included abnormal sonographic findings other than short long bones, suspected genetic syndromes, chromosomal abnormalities, and abnormal Doppler flow indices. Follow-up was carried out by telephone questionnaire. Results: During the study period, 54 (24.32%) women met inclusion criteria. Mean gestational age at delivery was 38.05 years (± 2.42 SD). Mean birth weight was 12–19th percentile according to the local fetal growth charts [2645 g (± 684 SD) 95% CI 2173–2980]. Median time for post-natal follow-up was 9.3 years (IQR 6.6–10.75). Growth below the 10th percentile was demonstrated in 27 (50%) children. 11 (20.37%) children were followed up by endocrinological clinics, of them 7 (12.96%) were treated with growth hormone. Three (5.6%) of the children were diagnosed with attention deficit hyperactivity disorder, an incidence that is considered lower than that of the general population (± 9%). Conclusions: Prenatal fetal isolated short long bones diagnosed during the late second and third trimester is associated with short stature. No neurodevelopmental impact was observed in our study group.

Original languageEnglish
Pages (from-to)459-463
Number of pages5
JournalArchives of Gynecology and Obstetrics
Issue number2
StatePublished - 1 Feb 2020


  • Long-term follow-up
  • Normal genetic evaluation
  • Normal sonographic evaluation
  • Short long bones


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