Long-term follow-up of partial splenectomy in Gaucher's disease

Ian J. Cohen*, Kalman Katz, Enrique Freud, Michael Zer, Rina Zaizov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Seven children with Gaucler's disease who underwent partial splenectomy were followed for 7 to 8 years. None of the children had systemic sepsis or symptoms related to liver enlargement. Bone crisis occurred in only tow children who had experienced bone crisis prior to partial splenectomy. This contrasts with the development of bone crises in five of six children who underwent total splenectomy at a similar age and who had previously been free of bone symptoms. Partial splenectomy should be regarded as a temporary solution in the treatment of hypersplenism and the mechanical compression related to the huge spleen. In 71% of the patients, massive enlargement and a severe to moderate degree of pancytopenia occurred again after 3 to 8 years; total splenectomy was required in three patients.

Original languageEnglish
Pages (from-to)345-347
Number of pages3
JournalAmerican Journal of Surgery
Volume164
Issue number4
DOIs
StatePublished - Oct 1992

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