TY - JOUR
T1 - Long-term efficacy of a novel ribose-cross-linked collagen dermal filler
T2 - A histologic and histomorphometric study in an animal model
AU - Pitaru, Sandu
AU - Noff, Matitiau
AU - Blok, Liat
AU - Nir, Eran
AU - Pitaru, Shahar
AU - Goldlust, Arie
AU - Savion, Naftali
PY - 2007/9
Y1 - 2007/9
N2 - BACKGROUND: Degradation and loss of the three-dimensional shape are the major causes of limited functional longevity of dermal fillers made of natural polymers as collagen and hyaluronic acid. OBJECTIVE: This study assessed the functional longevity of a new ribose-cross-linked collagen filler during 24 months in an animal model. METHODS: Ribose-cross-linked collagen (Evolence, Colbar Life Sciences Ltd), glutaraldehyde-cross-linked collagen (Zyplast, Inamed Inc.), and non-cross-linked collagen (Zyderm, Inamed Inc.) were injected in the rabbit ear dermis. Biopsies obtained at 1, 6, 12, and 24 months were histomorphometrically assessed for shape preservation and cell repopulation. RESULT: The three-dimensional shape of Evolence remained stable during 24 months. Zyderm and Zyplast lost their three-dimensional shape after 6 months. Although the cell density in Evolence remained stable over time, that in Zyplast and Zyderm decreased significantly at 12 and 24 months. CONCLUSION: Ribose-cross-linked collagen is endowed with a higher functional longevity as assessed in an animal model when compared with the most used collagen-based dermal fillers.
AB - BACKGROUND: Degradation and loss of the three-dimensional shape are the major causes of limited functional longevity of dermal fillers made of natural polymers as collagen and hyaluronic acid. OBJECTIVE: This study assessed the functional longevity of a new ribose-cross-linked collagen filler during 24 months in an animal model. METHODS: Ribose-cross-linked collagen (Evolence, Colbar Life Sciences Ltd), glutaraldehyde-cross-linked collagen (Zyplast, Inamed Inc.), and non-cross-linked collagen (Zyderm, Inamed Inc.) were injected in the rabbit ear dermis. Biopsies obtained at 1, 6, 12, and 24 months were histomorphometrically assessed for shape preservation and cell repopulation. RESULT: The three-dimensional shape of Evolence remained stable during 24 months. Zyderm and Zyplast lost their three-dimensional shape after 6 months. Although the cell density in Evolence remained stable over time, that in Zyplast and Zyderm decreased significantly at 12 and 24 months. CONCLUSION: Ribose-cross-linked collagen is endowed with a higher functional longevity as assessed in an animal model when compared with the most used collagen-based dermal fillers.
UR - http://www.scopus.com/inward/record.url?scp=34548349081&partnerID=8YFLogxK
U2 - 10.1111/j.1524-4725.2007.33218.x
DO - 10.1111/j.1524-4725.2007.33218.x
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AN - SCOPUS:34548349081
SN - 1076-0512
VL - 33
SP - 1045
EP - 1054
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 9
ER -