Long-term effects of prenatal stress experience and postnatal maternal separation on emotionality and attentional processes

Julia Lehmann, Thomas Stöhr, Joram Feldon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Postnatal environmental manipulations naturally occur on the background of prenatal experiences. In the laboratory rat, both pre- and postnatal environmental manipulations have been shown to alter adult behaviour. Additionally, it has been demonstrated that the consequences of postnatal manipulations can be altered by previous prenatal stress experience (PS). In the present study, we investigated long-term behavioural consequences of combined PS and postnatal experience, namely repeated maternal separation (MS). PS primarily increases emotionality and fear-related behaviour, while postnatal repeated MS has been previously reported to affect primarily attentional processes. Thus, we tested adult male and female Wistar rats on paradigms involving both emotionality and attention, namely open field, prepulse inhibition (PPI), and latent inhibition (LI) in the active avoidance and the conditioned emotional response paradigms. In line with previous reports, PS decreased open-field locomotion and impaired avoidance learning (increased emotionality), while MS enhanced LI (selective attention) and improved avoidance learning. Further, PS also increased PPI. There was little interaction between the two manipulations: The increased PPI seen after PS was normalised by MS, and the MS-induced enhancement of LI (using the active avoidance paradigm) was not evident in subjects previously subjected to PS. Taken together, these results suggest that the effects of PS and repeated MS are not synergistic in any of the investigated paradigms but can antagonise each other. Thus, in assessing the effects of postnatal manipulations, attention should be paid to the inadvertent occurrence of prenatal stress. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)133-144
Number of pages12
JournalBehavioural Brain Research
Volume107
Issue number1-2
DOIs
StatePublished - Jan 2000
Externally publishedYes

Funding

FundersFunder number
Swiss Federal Institute of Technology Zürich

    Keywords

    • Latent inhibition
    • Maternal separation
    • Open field
    • Prenatal stress
    • Prepulse inhibition
    • Sex differences

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