Long-term effect of antiangiogenic therapy for retinopathy of prematurity up to 5 years of follow-up

María A. Martínez-Castellanos, Shulamit Schwartz, Myriam L. Hernández-Rojas, Veronica A. Kon-Jara, Gerardo García-Aguirre, José L. Guerrero-Naranjo, R. V.Paul Chan, Hugo Quiroz-Mercado*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


PURPOSE:: To evaluate ocular function and systemic development in premature infants treated with intravitreal bevacizumab injections for retinopathy of prematurity over a period of 5 years. METHODS:: A prospective, interventional, noncomparative case study. The primary outcome measure was visual acuity. The secondary outcomes were structural assessment, other ocular functional measurements, and developmental state. RESULTS:: Eighteen eyes of 13 consecutive patients were divided into 3 groups: Group 1, Stage 4 unresponsive to previous conventional treatment (n = 4); Group 2, in which conventional treatment was difficult or impossible because of inadequate visualization of the retina (n = 5); and Group 3, newly diagnosed high-risk prethreshold or threshold retinopathy of prematurity (n = 9). All patients showed initial regression of neovascularization. One patient was diagnosed with recurrence of neovascularization and was treated with intravitreal bevacizumab. Visual acuity was preserved, and median vision was 20/25 (excluding 2 operated eyes). Twelve eyes developed mainly low myopia over the years, with an overall mean value of 3.2 diopters. Electroretinograph was normal in 4 eyes that had no previous detachment. One patient showed delay in growth and neurodevelopment, whereas all the others were within the normal range. CONCLUSION:: Five years of follow-up in a small series suggest that intravitreal bevacizumab for retinopathy of prematurity results in apparently preserved ocular function and systemic development.

Original languageEnglish
Pages (from-to)329-338
Number of pages10
Issue number2
StatePublished - Feb 2013
Externally publishedYes


  • anti vascular endothelial growth factor (VEGF)
  • antiangiogenic
  • bevacizumab
  • retinopathy of prematurity (ROP)


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