Long-term complications of past glucocorticoid use

Luciana P.C. Seguro, Cristina Rosario, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review


Glucocorticoids (GC) are essential in the management of several medical conditions but its long-term use is associated with complications in diverse organs and systems. The aim of the present study is to review the long-term complications of past GC use.Permanent damage related to GC can affect patient's life even years after its withdrawal. Classical examples are cataracts and esthetic problems like skin atrophy, striae, acne and obesity. Interestingly, for some complications, the risk of an incident event can persist for past GC use. Higher risks of osteoporosis, osteonecrosis, cardiovascular disease, infections and cancer have been associated with prior GC therapy. These evidences reinforce the importance of limiting our GC prescriptions at its lower possible dose.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalAutoimmunity Reviews
Issue number5
StatePublished - Mar 2013


  • Adverse effects
  • Complications
  • Glucocorticoids
  • Long-term


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