Long-term complications associated with the management of sinonasal malignancies: a single center experience

Einav G. Levin*, Sharon Tzelnick, Daniel Yaacobi, Igor Vainer, Aviram Mizrachi, Aron Popovtzer, Ethan Soudry

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective. The aim of this study was to review the long-term complications associated with treatment of patients with sinonasal malignancies (SNMs) and risk factors for these complications. Methods. A retrospective analysis of all patients treated for SNMs at a tertiary care center between 2001 and 2018. A total of 77 patients were included. The primary outcome measure was post-treatment long-term complications. Results. Overall, long-term complications were identified in 41 patients (53%), and the most common were sinonasal (22 patients, 29%) and orbital/ocular-related (18 patients, 23%). In a multivariate regression analysis, irradiation was the only significant predictor of long-term complications (p = 0.001, OR = 18.86, CI = 3.31-107.6). No association was observed between long-term complications and tumour stage, surgical modality, or radiation dose/modality. Mean radiation dose ≥ 50 Gy to the optic nerve was associated with grade ≥ 3 visual acuity impairment (100% vs 3%; p = 0.006). Radiation therapy for disease recurrence was associated with additional long-term complications (56% vs 11%; p = 0.04). Conclusions. Treatment of SNMs has substantial long-term complications, which are significantly associated with radiation therapy.

Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalActa Otorhinolaryngologica Italica
Issue number3
StatePublished - Jun 2023


  • long-term care
  • nose
  • patient care
  • radiotherapy


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