Long-term clinical outcome of patients with gastric gastrointestinal stromal tumors

Yaakov Maor*, Benjamin Avidan, Ehud Melzer, Simon Bar-Meir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background About 10-30% of gastrointestinal stromal tumors prove to be malignant. Nevertheless, the natural history of gastric gastrointestinal stromal tumors has not been fully elucidated. Aims To determine the long-term clinical outcome of nonresected gastric gastrointestinal stromal tumors.Methods Clinical follow-up of patients with endosonographic characteristics compatible with gastric gastrointestinal stromal tumors was conducted based on Israeli population registry. Lesions with features suggesting malignancy were usually referred to surgery. Follow-up endoscopic ultrasound examinations of nonoperated patients were reviewed. Results Seventy-one patients with presumable gastric gastrointestinal stromal tumors were followed. Seventeen patients underwent operation; median tumor size was 43 mm (range 29-70 mm). Within a median of 43 months (range 2-131 months) ten patients died of causes unrelated to gastrointestinal stromal tumor. Forty-four patients with endosonographic diagnosis of gastric gastrointestinal stromal tumors were followed expectantly for a median of 12 years (range 5-15 years). All these patients are alive and without complications associated with gastrointestinal stromal tumor. Follow-up endoscopic ultrasound examinations demonstrated no change in tumor size in six, decrease (by 1-5 mm) in six, and increase (by 2-21 mm) in eight. Conclusions Therapeutic decisions guiding surgical interventions may be based on clinical presentation, comorbidity, and endosonographic characteristics. Nonoperated patients may be safely followed conservatively.

Original languageEnglish
Pages (from-to)2893-2898
Number of pages6
JournalDigestive Diseases and Sciences
Issue number10
StatePublished - Oct 2010
Externally publishedYes


  • Clinical outcome
  • Endoscopic ultrasound
  • Gastric
  • Gastrointestinal stromal tumors
  • Subepithelial lesions


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