Long-Range Fluorescence Propagation in Amyloidogenic β-Sheet Films and Fibers

Boris Apter, Boris Fainberg, Amir Handelman, Igor Lapsker, Antonella Accardo, Carlo Diaferia, Giancarlo Morelli, Gil Rosenman

Research output: Contribution to journalArticlepeer-review

Abstract

Newly developed PEGylated phenylalanine peptide derivatives (PEG-F6) can self-assemble to form hybrid multifunctional nanostructures of homogeneous thin polymer films and amyloid-like fibers. Both adopt a β-sheet architecture and acquire the unique properties of visible fluorescence (FL) found in β-sheet amyloid fibrils also associated with neurodegenerative diseases. A new paradigm observed in PEG-F6 amyloid-like fibers is reported, which demonstrates unique FL and optical absorption (OA) covering the entire visible region. Despite the full overlap of the FL and OA spectra, the FL propagates for an unexpectedly large distance of hundreds of micrometers in these fibers. A new non-waveguiding mechanism of FL light energy transfer in amyloidogenic fibers is proposed based on photon reabsorption theory. The discovered quasi-white FL of PEG-F6 β-sheet amyloidogenic fibers and films consists of the newly observed green FL band along the known blue FL band. The proof-of-concept of long sub-millimeter range FL propagation in specially grown amyloidogenic PEG-F6 fiber-photonic probes is reported. The results indicate that FL can propagate in nanoscale fibers and suggest biomedical applications for FL monitoring of disease-related ultrathin amyloid fibrils and in integrated photonics for optogenetics.

Original languageEnglish
Article number2000056
JournalAdvanced Optical Materials
Volume8
Issue number9
DOIs
StatePublished - 1 May 2020

Keywords

  • PEGylated hexaphenylalanines
  • amyloid-like fibers
  • amyloidogenic thin films
  • anomalous long-range fluorescence propagation
  • hybrid polymer–peptide compounds
  • intrinsic beta-sheet structure
  • wideband visible fluorescence

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