Long range correlations in healthy dynamics and their breakdown with disease: A new paradigm for physiological monitoring

Ary L. Goldberger, Chung Kang Peng, Joseph Mietus, Jeffrey M. Hausdorff, Shlomo Havlin, H. Eugene Stanley

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We propose a new framework for conceptualizing and quantitating the dynamics of health and disease, using neuroautonomic regulation of the heartbeat as a model system. This theory is based on two postulates: 1) Complex physiological systems operate far from equilibrium and demonstrate long-range correlations indicative of a fractal (scale-invariant) mechanism; 2) Pathologic dynamics are marked by a breakdown in this long-range correlation behavior.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
EditorsJean Pierre Morucci, Jean Louis Coatrieux, Swamy Laxminarayan, Robert Plonsey
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages969-970
Number of pages2
ISBN (Electronic)0780307852
DOIs
StatePublished - 1992
Externally publishedYes
Event14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 - Paris, France
Duration: 29 Oct 19921 Nov 1992

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume3
ISSN (Print)1557-170X

Conference

Conference14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Country/TerritoryFrance
CityParis
Period29/10/921/11/92

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