TY - JOUR
T1 - Long-range charge transport in single G-quadruplex DNA molecules
AU - Livshits, Gideon I.
AU - Stern, Avigail
AU - Rotem, Dvir
AU - Borovok, Natalia
AU - Eidelshtein, Gennady
AU - Migliore, Agostino
AU - Penzo, Erika
AU - Wind, Shalom J.
AU - Di Felice, Rosa
AU - Skourtis, Spiros S.
AU - Cuevas, Juan Carlos
AU - Gurevich, Leonid
AU - Kotlyar, Alexander B.
AU - Porath, Danny
N1 - Publisher Copyright:
© 2014 Macmillan Publishers Limited. All rights reserved.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - DNA and DNA-based polymers are of interest in molecular electronics because of their versatile and programmable structures. However, transport measurements have produced a range of seemingly contradictory results due to differences in the measured molecules and experimental set-ups, and transporting significant current through individual DNA-based molecules remains a considerable challenge. Here, we report reproducible charge transport in guanine-quadruplex (G4) DNA molecules adsorbed on a mica substrate. Currents ranging from tens of picoamperes to more than 100 pA were measured in the G4-DNA over distances ranging from tens of nanometres to more than 100 nm. Our experimental results, combined with theoretical modelling, suggest that transport occurs via a thermally activated long-range hopping between multi-tetrad segments of DNA. These results could re-ignite interest in DNA-based wires and devices, and in the use of such systems in the development of programmable circuits.
AB - DNA and DNA-based polymers are of interest in molecular electronics because of their versatile and programmable structures. However, transport measurements have produced a range of seemingly contradictory results due to differences in the measured molecules and experimental set-ups, and transporting significant current through individual DNA-based molecules remains a considerable challenge. Here, we report reproducible charge transport in guanine-quadruplex (G4) DNA molecules adsorbed on a mica substrate. Currents ranging from tens of picoamperes to more than 100 pA were measured in the G4-DNA over distances ranging from tens of nanometres to more than 100 nm. Our experimental results, combined with theoretical modelling, suggest that transport occurs via a thermally activated long-range hopping between multi-tetrad segments of DNA. These results could re-ignite interest in DNA-based wires and devices, and in the use of such systems in the development of programmable circuits.
UR - https://www.scopus.com/pages/publications/84923264041
U2 - 10.1038/nnano.2014.246
DO - 10.1038/nnano.2014.246
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C2 - 25344689
AN - SCOPUS:84923264041
SN - 1748-3387
VL - 9
SP - 1040
EP - 1046
JO - Nature Nanotechnology
JF - Nature Nanotechnology
IS - 12
ER -