Long-lived fluorescence of homopolymeric guanine-cytosine DNA duplexes

Ignacio Vayá; Pascale Changenet-Barret; Thomas Gustavsson; Dragoslav Zikich; Alexander Kotlyar; Dimitra Markovitsi

doi:10.1039/c0pp00201a

Long-lived fluorescence of homopolymeric guanine-cytosine DNA duplexes

Ignacio Vayá, Pascale Changenet-Barret, Thomas Gustavsson, Dragoslav Zikich, Alexander Kotlyar, Dimitra Markovitsi^*

^*Corresponding author for this work

Biochemistry Molecular Biology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The fluorescence spectrum of the homopolymeric double helix poly(dG)·poly(dC) is dominated by emission decaying on the nanosecond time-scale, as previously reported for the alternating homologue poly(dGdC)·poly(dGdC). Thus, energy trapping over long periods of time is a common feature of GC duplexes which contrast with AT duplexes. The impact of such behaviour on DNA photodamage needs to be evaluated.

Original language	English
Pages (from-to)	1193-1195
Number of pages	3
Journal	Photochemical and Photobiological Sciences
Volume	9
Issue number	9
DOIs	https://doi.org/10.1039/c0pp00201a
State	Published - Sep 2010

Funding

Funders	Funder number
Seventh Framework Programme	228334

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AU - Changenet-Barret, Pascale

AU - Gustavsson, Thomas

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AU - Kotlyar, Alexander

AU - Markovitsi, Dimitra

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AB - The fluorescence spectrum of the homopolymeric double helix poly(dG)·poly(dC) is dominated by emission decaying on the nanosecond time-scale, as previously reported for the alternating homologue poly(dGdC)·poly(dGdC). Thus, energy trapping over long periods of time is a common feature of GC duplexes which contrast with AT duplexes. The impact of such behaviour on DNA photodamage needs to be evaluated.

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Long-lived fluorescence of homopolymeric guanine-cytosine DNA duplexes

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