TY - JOUR
T1 - Long-lasting effect of early handling on the peripheral benzodiazepine receptor
AU - Weizman, Ronit
AU - Lehmann, Julia
AU - Leschiner, Svetlana
AU - Allmann, Isabelle
AU - Stoehr, Thomas
AU - Heidbreder, Christian
AU - Domeney, Annette
AU - Feldon, Joram
AU - Gavish, Moshe
N1 - Funding Information:
This research was supported by grants from the Swiss Federal Institute of Technology, Zürich, to J.F., by a grant from the National Institute for Psychobiology in Israel to M.G. and S.L., and by a grant from the Technion V.P.R. Fund—Hirshenstrauss-Gutman Medical Research Fund to M.G. We would like to thank Peter Schmid for technical support, Ruth Singer for editing the manuscript, and the animal care team for their assistance.
PY - 1999/12
Y1 - 1999/12
N2 - The present study determined the impact of early handling (EH) in rats on behavioral response to environmental stress and on peripheral benzodiazepine receptor (PBR) binding characteristics (B(max) and K(d)) in various organs. The behavioral consequences of EH in rats were expressed as increased exploratory activity in an open-field paradigm, when compared with nonhandled control rats. These findings are interpreted in terms of decreased emotionality. The biochemical consequences of EH, in both male and female rats, were expressed as the upregulation of PBR in the adrenal and kidney and the downregulation of gonadal (testis and ovary) PBR. It is possible that the long-lasting adrenal and renal changes in PBR expression in EH rats may enable better regulation of the hypothalamic-pituitary-adrenal axis, renin- angiotensin system, and autonomic nervous system responses to stress in adulthood. The significance of the EH-induced reduction in gonadal PBR for gonadal activity in adulthood is as yet unclear.
AB - The present study determined the impact of early handling (EH) in rats on behavioral response to environmental stress and on peripheral benzodiazepine receptor (PBR) binding characteristics (B(max) and K(d)) in various organs. The behavioral consequences of EH in rats were expressed as increased exploratory activity in an open-field paradigm, when compared with nonhandled control rats. These findings are interpreted in terms of decreased emotionality. The biochemical consequences of EH, in both male and female rats, were expressed as the upregulation of PBR in the adrenal and kidney and the downregulation of gonadal (testis and ovary) PBR. It is possible that the long-lasting adrenal and renal changes in PBR expression in EH rats may enable better regulation of the hypothalamic-pituitary-adrenal axis, renin- angiotensin system, and autonomic nervous system responses to stress in adulthood. The significance of the EH-induced reduction in gonadal PBR for gonadal activity in adulthood is as yet unclear.
KW - Early handling
KW - Locomotor activity
KW - Peripheral-type benzodiazepine receptor
KW - Rats
KW - Steroidogenesis
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=0032713532&partnerID=8YFLogxK
U2 - 10.1016/S0091-3057(99)00138-0
DO - 10.1016/S0091-3057(99)00138-0
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AN - SCOPUS:0032713532
SN - 0091-3057
VL - 64
SP - 725
EP - 729
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 4
ER -