Localization of beta receptors in the anterior segment of the rat eye by a fluorescent analogue of propranolol

M. Lahav, E. Melamed, Z. Dafna, D. Atlas

Research output: Contribution to journalArticlepeer-review

Abstract

A fluorescent analogue of propranolol, 9-AAP, was injected intravenously in order to detect beta-adrenergic receptors in the anterior segment of the albino rat eye. Specific 9-AAP fluorescence was noted along cell membranes of the ciliary epithelium and to a lesser extent in the walls of blood vessels in the ciliary processes and episclera at the limbus. The iris showed maximum 9-AAP binding in the region of the sphincter muscle. These data suggest that 9-AAP may label beta receptors in the anterior segment of the rat eye.

Original languageEnglish
Pages (from-to)645-651
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume17
Issue number7
StatePublished - 1978
Externally publishedYes

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