Localization of an ataxia-telangiectasia gene to an ∼500-kb interval on chromosome 11q23.1: Linkage analysis of 176 families by an international consortium

Ethan Lange, Anna Lise Borresen, Xiaoguang Chen, Luciana Chessa, Sujata Chiplunkar, Patrick Concannon, Sugandha Dandekar, Steven Gerken, Kenneth Lange, Teresa Liang, Carmel McConville, Jeff Polakow, Oscar Porras, Galit Rotman, Ozden Sanal, Sepideh Sheikhavandi, Yosef Shiloh, Eric Sobel, Malcolm Taylor, Milhan TelatarSharon Teraoka, Aslihan Tolun, Nitin Udar, Nancy Uhrhammer, Lina Vanagaite, Zhijun Wang, Beth Wapelhorst, Jocyndra Wright, Huan Ming Yang, Lan Yang, Yael Ziv, Richard A. Gatti*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a 20-point linkage analysis map of chromosome 11q22-23 that is based on genotyping 249 families (59 CEPH and 190 A-T). Monte Carlo linkage analyses of 176 ataxia-telangiectasia (A-T) families localizes the major A-T locus to the region between S1819(A4) and S1818(A2). When seven nonlinking families were excluded from subsequent analyses, a 2-lod support interval of ∼500 kb was identified between S1819(A4) and S1294. No recombinants were observed between A-T and markers S384, B7, S535, or S1294. Only 17 of the international consortium families have been assigned to complementation groups. The available evidence favors either a cluster of A-T genes on chromosome 11 or intragenic defects in a single gene.

Original languageEnglish
Pages (from-to)112-119
Number of pages8
JournalAmerican Journal of Human Genetics
Volume57
Issue number1
StatePublished - Jul 1995

Fingerprint

Dive into the research topics of 'Localization of an ataxia-telangiectasia gene to an ∼500-kb interval on chromosome 11q23.1: Linkage analysis of 176 families by an international consortium'. Together they form a unique fingerprint.

Cite this