Local Tolerance and Biodegradability of a Novel Artificial Dura Mater Graft Following Implantation Onto a Dural Defect in Rabbits

Yuval Ramot, Sagi Harnof, Ido Klein, Netanel Amouyal, Michal Steiner, Nora Nseir Manassa, Amir Bahar, Serge Rousselle, Abraham Nyska*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Dura mater defects are a common problem following neurosurgery. Dural grafts are used to repair these defects; among them are biodegradable polymeric synthetic grafts. ArtiFascia is a novel synthetic and fibrous Dural graft, composed of poly(l-lactic-co-caprolactone acid) (PLCL) and poly(d-lactic-co-caprolactone acid). In this study, the biodegradability and local tolerance of ArtiFascia was evaluated in rabbits and compared with a bovine collagen matrix as a reference control. ArtiFascia implantation resulted in the formation of neo-dura at the site of implantation and recovery of the dural damage and the calvaria bone above. The implanted graft was completely absorbed after 12 months and the remaining macrophages were morphologically consistent with the anti-inflammatory M2-like phenotype, which contributes to tissue healing and are not pro-inflammatory. The site of the drilled skull bone had a continuous smooth surface, without exuberant tissue or inflammation and a newly formed trabecular bone formation indicated the healing process of the bone. These results support the local tolerability and biodegradability of ArtiFascia when used as a dural graft in rabbits. This study suggests that PLCL-based grafts including ArtiFascia are safe and effective to repair Rabbit Dura.

Original languageEnglish
Pages (from-to)738-746
Number of pages9
JournalToxicologic Pathology
Volume48
Issue number6
DOIs
StatePublished - 1 Aug 2020
Externally publishedYes

Funding

FundersFunder number
Nurami Medical Nanofiber Technology

    Keywords

    • CSF
    • PDLCL
    • PLCL
    • biodegradability
    • biodegradable materials
    • dura mater
    • local tolerability

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