Local microwave hyperthermia in the treatment of carcinoma of the prostate1

A. Yerushalmi, A. Shani, Y. Fishelovitz, J. Arielly, D. Singer, E. Levy, R. Katsnelson, E. Rakowsky, J. A. Stein

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical electromagnetic hyperthermia system has been in use at the Kaplan Hospital since 1980, for treating patients with hyperthermia combined with radio- or chemotherapy. For prostatic tumors, hyperthermia at 43 C is achieved in the prostatic mass using microwaves of 2.45 GHz. with simultaneous cooling of the rectal mucosa and the rectal wall. Thirty-two patients with carcinoma of the prostate have been treated: 4 with heat alone. 20 with hyperthermia combined with radiotherapy, and 8 with hyperthermia combined with hormonal therapy. Follow-up was carried out up to 34 months. Objective local tumor regression was achieved in 3 out of 4 patients treated by heal alone, but the patients relapsed after 6 months. All the 20 patients treated with combined hyperthermia and radiotherapy responded to treatment. Patients treated with combined hyperthermia and hormone therapy responded locally to treatment but died of their metastatic disease, or of unrelated diseases with a follow-up period up to 31 months. Hyperthermia did not increase morbidity beyond that expected for radiation therapy.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalOncology
Volume43
Issue number5
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • Carcinoma
  • Hormone therapy
  • Local microwave hyperthermia
  • Prostate
  • Radiation

Fingerprint

Dive into the research topics of 'Local microwave hyperthermia in the treatment of carcinoma of the prostate1'. Together they form a unique fingerprint.

Cite this