Local generation of multineuronal spike sequences in the hippocampal CA1 region

Eran Stark, Lisa Roux, Ronny Eichler, György Buzsáki

Research output: Contribution to journalArticlepeer-review

Abstract

Sequential activity of multineuronal spiking can be observed during theta and high-frequency ripple oscillations in the hippocampal CA1 region and is linked to experience, but the mechanisms underlying such sequences are unknown. We compared multineuronal spiking during theta oscillations, spontaneous ripples, and focal optically induced high-frequency oscillations ("synthetic" ripples) in freely moving mice. Firing rates and rate modulations of individual neurons, and multineuronal sequences of pyramidal cell and interneuron spiking, were correlated during theta oscillations, spontaneous ripples, and synthetic ripples. Interneuron spiking was crucial for sequence consistency. These results suggest that participation of single neurons and their sequential order in population events are not strictly determined by extrinsic inputs but also influenced by local-circuit properties, including synapses between local neurons and single-neuron biophysics.

Original languageEnglish
Pages (from-to)10521-10526
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number33
DOIs
StatePublished - 18 Aug 2015

Keywords

  • Hippocampus
  • Mouse
  • Optogenetics
  • Ripples
  • Temporal precision

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