Local cutaneous reaction induced by subcutaneous interleukin-2 and interferon alpha-2a immunotherapy following ABMT

L. Klapholz, A. Ackerstein, M. A. Goldenhersh, D. Vardy, A. Nagler

Research output: Contribution to journalArticlepeer-review

Abstract

Immunotherapy using subcutaneous injections of recombinant interleukin-2 (IL-2) and recombinant interferon alpha-2a (IFN-α) for advanced hematologic and solid tumors is rapidly developing. We report five patients with Hodgkin's and non-Hodgkin's lymphoma who developed a local cutaneous reaction consisting of inflammatory painful nodules with a central multiloculated vesicle at the site of sc injections of IL-2 and IFN-α immunotherapy following ABMT. This is the first report of a local cutaneous adverse reaction induced by IL-2 and IFN-α immunotherapy following ABMT.

Original languageEnglish
Pages (from-to)443-446
Number of pages4
JournalBone Marrow Transplantation
Volume11
Issue number6
StatePublished - 1993
Externally publishedYes

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