Liver metastases from colorectal cancer: Regional intra-arterial treatment following failure of systemic chemotherapy

A. Cyjon*, M. Neuman-Levin, E. Rakowsky, F. Greif, A. Belinky, E. Atar, R. Hardoff, B. Brenner, A. Sulkes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This study was designed to determine response rate, survival and toxicity associated with combination chemotherapy delivered intra-arterially to liver in patients with hepatic metastases of colorectal origin refractory to standard systemic treatment. A total of 28 patients who failed prior systemic treatment with fluoropyrimidines received a median of 5 cycles of intra-arterial treatment consisting of 5-fluorouracil 700 mg/m 2/d, leucovorin 120 mg/m 2/d, and cisplatin 20 mg/m 2/d for 5 consecutive days. Cycles were repeated at intervals of 5-6 weeks. A major response was achieved in 48% of patients: complete response in 8% and partial response in 40%. The median duration of response was 11.5 months. Median survival was 12 months at a median follow up of 12 months. On multivariate analysis, the only variables with a significant impact on survival were response to treatment and performance status. Toxicity was moderate: grades III-IV neutropenia occurred in 29% of patients. Most of the patients complained of fatigue lasting for a few days following each cycle. There were no cases of hepatobiliary toxicity. These findings indicate that regional intra-arterial treatment should be considered in selected patients with predominantly liver disease following failure of standard treatment.

Original languageEnglish
Pages (from-to)504-508
Number of pages5
JournalBritish Journal of Cancer
Volume85
Issue number4
DOIs
StatePublished - 17 Aug 2001

Keywords

  • Colorectal cancer
  • Liver metastases
  • Regional intra-arterial

Fingerprint

Dive into the research topics of 'Liver metastases from colorectal cancer: Regional intra-arterial treatment following failure of systemic chemotherapy'. Together they form a unique fingerprint.

Cite this