Lithium intoxication due to carbamazepine-induced renal failure

Haim Mayan; Nina Golubev; Dganit Dinour; Zvi Farfel

doi:10.1345/aph.10157

Lithium intoxication due to carbamazepine-induced renal failure

Haim Mayan^*, Nina Golubev, Dganit Dinour, Zvi Farfel

^*Corresponding author for this work

Clinical Departments

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

OBJECTIVE: To report the case of a patient with manic-depressive disorder who developed lithium intoxication following carbamazepine-induced acute renal failure. CASE SUMMARY: A 33-year-old white man with bipolar manic-depressive disorder was treated with lithium for the last 18 months. Three weeks prior to admission, carbamazepine 600 mg was added to the drug regimen due to a recurrence of the psychiatric disorder. He was admitted with signs of lithium intoxication. Acute renal failure due to carbamazepine-induced interstitial nephritis was diagnosed. DISCUSSION: The combination of carbamazepine and lithium is known to cause neurotoxicity. We describe a different interaction in which the toxic lithium concentrations were the result of carbamazepine-induced acute renal failure. CONCLUSIONS: When considering adding carbamazepine to lithium, careful follow-up of the patients is warranted to prevent this indirect drug interaction.

Original language	English
Pages (from-to)	560-562
Number of pages	3
Journal	Annals of Pharmacotherapy
Volume	35
Issue number	5
DOIs	https://doi.org/10.1345/aph.10157
State	Published - 2001

Keywords

Carbamazepine
Lithium
Renal failure

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10.1345/aph.10157

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title = "Lithium intoxication due to carbamazepine-induced renal failure",

abstract = "OBJECTIVE: To report the case of a patient with manic-depressive disorder who developed lithium intoxication following carbamazepine-induced acute renal failure. CASE SUMMARY: A 33-year-old white man with bipolar manic-depressive disorder was treated with lithium for the last 18 months. Three weeks prior to admission, carbamazepine 600 mg was added to the drug regimen due to a recurrence of the psychiatric disorder. He was admitted with signs of lithium intoxication. Acute renal failure due to carbamazepine-induced interstitial nephritis was diagnosed. DISCUSSION: The combination of carbamazepine and lithium is known to cause neurotoxicity. We describe a different interaction in which the toxic lithium concentrations were the result of carbamazepine-induced acute renal failure. CONCLUSIONS: When considering adding carbamazepine to lithium, careful follow-up of the patients is warranted to prevent this indirect drug interaction.",

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AU - Mayan, Haim

AU - Golubev, Nina

AU - Dinour, Dganit

AU - Farfel, Zvi

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N2 - OBJECTIVE: To report the case of a patient with manic-depressive disorder who developed lithium intoxication following carbamazepine-induced acute renal failure. CASE SUMMARY: A 33-year-old white man with bipolar manic-depressive disorder was treated with lithium for the last 18 months. Three weeks prior to admission, carbamazepine 600 mg was added to the drug regimen due to a recurrence of the psychiatric disorder. He was admitted with signs of lithium intoxication. Acute renal failure due to carbamazepine-induced interstitial nephritis was diagnosed. DISCUSSION: The combination of carbamazepine and lithium is known to cause neurotoxicity. We describe a different interaction in which the toxic lithium concentrations were the result of carbamazepine-induced acute renal failure. CONCLUSIONS: When considering adding carbamazepine to lithium, careful follow-up of the patients is warranted to prevent this indirect drug interaction.

AB - OBJECTIVE: To report the case of a patient with manic-depressive disorder who developed lithium intoxication following carbamazepine-induced acute renal failure. CASE SUMMARY: A 33-year-old white man with bipolar manic-depressive disorder was treated with lithium for the last 18 months. Three weeks prior to admission, carbamazepine 600 mg was added to the drug regimen due to a recurrence of the psychiatric disorder. He was admitted with signs of lithium intoxication. Acute renal failure due to carbamazepine-induced interstitial nephritis was diagnosed. DISCUSSION: The combination of carbamazepine and lithium is known to cause neurotoxicity. We describe a different interaction in which the toxic lithium concentrations were the result of carbamazepine-induced acute renal failure. CONCLUSIONS: When considering adding carbamazepine to lithium, careful follow-up of the patients is warranted to prevent this indirect drug interaction.

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KW - Lithium

KW - Renal failure

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Lithium intoxication due to carbamazepine-induced renal failure

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