Abstract
OBJECTIVE: To report the case of a patient with manic-depressive disorder who developed lithium intoxication following carbamazepine-induced acute renal failure. CASE SUMMARY: A 33-year-old white man with bipolar manic-depressive disorder was treated with lithium for the last 18 months. Three weeks prior to admission, carbamazepine 600 mg was added to the drug regimen due to a recurrence of the psychiatric disorder. He was admitted with signs of lithium intoxication. Acute renal failure due to carbamazepine-induced interstitial nephritis was diagnosed. DISCUSSION: The combination of carbamazepine and lithium is known to cause neurotoxicity. We describe a different interaction in which the toxic lithium concentrations were the result of carbamazepine-induced acute renal failure. CONCLUSIONS: When considering adding carbamazepine to lithium, careful follow-up of the patients is warranted to prevent this indirect drug interaction.
Original language | English |
---|---|
Pages (from-to) | 560-562 |
Number of pages | 3 |
Journal | Annals of Pharmacotherapy |
Volume | 35 |
Issue number | 5 |
DOIs | |
State | Published - 2001 |
Keywords
- Carbamazepine
- Lithium
- Renal failure