Lithium as an immunologic adjuvant

Louis Shenkman*, William Borkowsky, Baron Shopsin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Lithium, an adenylate cyclase inhibitor, stimulates a variety of in vitro indices of immune function, including proliferation of lymphocytes in response to mitogens, rosette formation by T-cells and phagocytosis by macrophages. Lithium enhances these immunologic responses at concentrations comparable to those achieved in patients receiving lithium for treatment of manic-depressive disorders. Lithium may prove to have important therapeutic applications as an immune adjuvant, particularly in immune deficiency states associated with excessive C-AMP production.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalMedical Hypotheses
Issue number1
StatePublished - Jan 1980
Externally publishedYes


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