Lipid oxidation kinetics in hemodialysis patients with and without history of myocardial infarction

Mona Boaz, Shmuel Smetana, Zipora Matas, Ariella Bor, Ilya Pinchuk, Menachem Fainaru, Manfred S. Green, Dov Lichtenberg

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In lipid oxidation kinetics studies, prevalent cardiovascular disease has been associated with shortened lag phase, the length of time preceding the onset of oxidation. Objectives: To examine, in vitro, copper-induced lipid oxidation kinetics in unfractionated serum from hemodialysis patients and to determine differences in kinetic parameters between patients with and without a history of CVD. Methods: Of the 76 patients enrolled in a study of oxidative stress in hemodialysis (44/76 with prevalent CVD, 53/76 males), 9 males with a history of myocardial infarction were selected and matched for age, diabetes and smoking status with 9 males from the non-CVD group. The kinetics of lipid oxidation was studied. Blood chemistry determinations including serum lipids, lipoproteins, hemostatic factors and serum malondialdehyde were obtained. Variables were compared using the t-test for independent samples with history of Ml entered as the categorical variable. Results: Tmax, the oxidation kinetic parameter defined as the time at which the rate of absorbing product accumulation was maximal, was significantly shorter in dialysis patients with a history of Ml than in those without (115.2 ± 38.5 vs. 162.7 ± 48.9 minutes, P = 0.04). Further, Tmax and MDA were negatively correlated to one another (r = -0.47, P = 0.04). Odds ratios indicate that each 1 minute increase in Tmax was associated with a 3% decrease in odds that a subject had a history of Ml. Conclusions: These findings indicate the presence of increased oxidative stress in hemodialysis patients with a history of Ml.

Original languageEnglish
Pages (from-to)692-696
Number of pages5
JournalIsrael Medical Association Journal
Volume5
Issue number10
StatePublished - Oct 2003

Keywords

  • Hemodialysis
  • Lipid oxidation kinetics
  • Myocardial infarction

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