Lipid metabolism in critical illness

Pnina Green, Miriam Theilla, Pierre Singer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Purpose of review This article describes recent findings regarding lipid metabolism in critical illness as well as in lipid therapy. Recent findings In critical illness, in the presence of a decrease in lipid absorption, adipose tissue lipolysis raises triglyceride levels. High-density lipoprotein and low-density lipoprotein are decreased because of impairment of lecithin-cholesterol acyltransferase, mainly in sepsis. In septic patients, lipid profile may be a predictor of survival. Nonsurvivors have lower levels of high-density lipoprotein and low-density lipoprotein. In metabolomic studies, most of the changes from baseline in septic patients were related to lipid metabolism. Lysophosphatidylcholine was also significantly lower in nonsurviving septic patients. Summary Lipid profile results are too often neglected by the clinician despite increasing knowledge in the modifications related to septic state as well as the importance of these values in the prognosis of the critically ill. Lipid administration (enterally or parenterally) should be guided by better knowledge of the lipid metabolism of the patient.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume19
Issue number2
DOIs
StatePublished - 1 Mar 2016

Keywords

  • critical illness
  • fish oil
  • lipid metabolism

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