Linomide administration following bone marrow transplantation in mice

Lola Weiss, Ali Abdul-Hai, Yoel Shufaro, Shoshanna Reich, Shimon Slavin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effect of linomide, an immunomodulatory drug, on natural killer (NK) cells and T cell-dependent immune responses following syngeneic or allogeneic bone marrow transplantation (BMT) was investigated in BALB/c mice inoculated with B-cell leukemia (BCL1). Linomide given in the drinking water had no impact on graft survival or graft versus leukemia (GVL) effects. Although linomide regulates anti-self reactivity in mice with experimental and spontaneous autoimmune disorders, the anti-tumor effects induced by allogeneic donor lymphocytes were not affected. This indicates that different mechanisms regulate anti-self and anti-leukemia effects. Alternatively, linomide might affect the homing of self-reactive lymphocytes to specific target organs in autoimmune disorders, although the homing process may not be relevant to the control of leukemia by allo-reactive lymphocytes.

Original languageEnglish
Pages (from-to)596-602
Number of pages7
JournalCancer Immunology, Immunotherapy
Issue number11-12
StatePublished - 2002
Externally publishedYes


  • B-cell leukemia
  • Bone marrow graft versus leukemia effect
  • Linomide
  • Murine leukemia
  • Transplantation


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