@article{d531622184414201a8dc24642584d82a,
title = "Linomide administration following bone marrow transplantation in mice",
abstract = "The effect of linomide, an immunomodulatory drug, on natural killer (NK) cells and T cell-dependent immune responses following syngeneic or allogeneic bone marrow transplantation (BMT) was investigated in BALB/c mice inoculated with B-cell leukemia (BCL1). Linomide given in the drinking water had no impact on graft survival or graft versus leukemia (GVL) effects. Although linomide regulates anti-self reactivity in mice with experimental and spontaneous autoimmune disorders, the anti-tumor effects induced by allogeneic donor lymphocytes were not affected. This indicates that different mechanisms regulate anti-self and anti-leukemia effects. Alternatively, linomide might affect the homing of self-reactive lymphocytes to specific target organs in autoimmune disorders, although the homing process may not be relevant to the control of leukemia by allo-reactive lymphocytes.",
keywords = "B-cell leukemia, Bone marrow graft versus leukemia effect, Linomide, Murine leukemia, Transplantation",
author = "Lola Weiss and Ali Abdul-Hai and Yoel Shufaro and Shoshanna Reich and Shimon Slavin",
note = "Funding Information: Acknowledgements We wish to thank the Danny Cunniff Leukemia Research Laboratory, the Gabrielle Rich Leukemia Research Foundation, the Cancer Treatment Research Foundation, the Novotny Trust, the Szydlowsky Foundation, the Fig Tree Foundation, and also Ronne and Donald Hess for their continuous support of our ongoing basic and clinical research.",
year = "2002",
doi = "10.1007/s00262-002-0311-5",
language = "אנגלית",
volume = "51",
pages = "596--602",
journal = "Cancer Immunology, Immunotherapy",
issn = "0340-7004",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "11-12",
}
