Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice

Lea Canetti, Haim Werner, Alicia Leikin-Frenkel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Streptozotocin (STZ)-induced diabetes in mice progresses with decreased desaturase activities and alterations in the metabolism of essential fatty acids (EFA). Objectives: Based on our previous studies with soybean oil that ameliorated the STZ damage in mice, we tested here the accountability of its main EFA components, i.e. linoleic acid (LA) and alpha linolenic acid (ALA), in the prevention of pancreas damage and Δ6 desaturase decrease. Materials and methods: Seven days after injection with STZ and EFA gavage, ICR mice were sacrificed. Plasma glucose and insulin levels, pancreas histology and liver fatty acid desaturases were analysed. Results: EFA reduced pancreas damage, insulin and glucose plasma levels and restored Δ6 desaturase activity and mRNA expression levels. Discussion: By reducing pancreas damage, EFA ameliorated insulin levels, Δ6 desaturase and fatty acid metabolism. LA further enhanced Fads2 promoter activity. Conclusion: EFA ameliorate STZ induced diabetes in mice.

Original languageEnglish
Pages (from-to)34-39
Number of pages6
JournalArchives of Physiology and Biochemistry
Issue number1
StatePublished - Feb 2014


FundersFunder number
Israel Diabetes Association
Yadgaroff Fundation, Israel


    • Alpha linolenic acid
    • Fatty acid desaturases
    • Linoleic acid
    • Pancreas
    • Type 1 diabetes mellitus


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