Linkage studies do not confirm the cytogenetic location of incontinentia pigmenti on Xp11

A. Sefiani, D. Sinnett, L. Abel, S. Szpiro-Tapia, S. Heuertz, I. Craig, N. Fraser, T. A. Kruse, M. Frydman, M. O. Peter, J. L. Schmutz, S. Gilgenkrantz, G. Mitchell, J. Frézal, S. Melançon, L. Lavergne, D. Labuda, M. C. Hors-Cayla

Research output: Contribution to journalArticlepeer-review

Abstract

Linkage studies have been performed in 5 incontinentia pigmenti (IP) families totaling 29 potentially informative meioses. Ten probes of the Xp arm were used, six of them were precisely localized on the X chromosome, using hamster x human somatic cell hybrids containing a broken X chromosome derived from an incontinentia pigmenti patient carrying an X;9 translocation [46,XX,t(X;9)(p11.21;q34)]. The following order for probes is proposed: pter-(DXS7, DXS146, DXS255)-IP1-(DXS14, DXS90)-DXS106-qter. The negative lod scores obtained exclude the possibility that in the families studied, the gene for IP is located in Xp11 or in the major part of the Xp arm.

Original languageEnglish
Pages (from-to)282-286
Number of pages5
JournalHuman Genetics
Volume80
Issue number3
DOIs
StatePublished - Nov 1988
Externally publishedYes

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