Linkage of fifty-seven microsatellite loci to bipolar disorder

Pablo V. Gejman; Maria Martinez; Qiuhe Cao; Eitan Friedman; Wade H. Berrettini; Lynn R. Goldin; Panayiota Koroulakis; Chris Ames; Melissa A. Lerman; Elliot S. Gershon

doi:10.1038/npp.1993.40

Linkage of fifty-seven microsatellite loci to bipolar disorder

Pablo V. Gejman^*
, Maria Martinez
, Qiuhe Cao
, Eitan Friedman
, Wade H. Berrettini
, Lynn R. Goldin
, Panayiota Koroulakis
, Chris Ames
, Melissa A. Lerman
, Elliot S. Gershon

^*Corresponding author for this work

Neurogenetics Branch
Institut National de la Sante et de la Re-Medicale
Karolinska Institutet
University Philadelphia

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.

Original language	English
Pages (from-to)	31-40
Number of pages	10
Journal	Neuropsychopharmacology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/npp.1993.40
State	Published - Aug 1993
Externally published	Yes

Keywords

Bipolar illness
GNASl
Human X-linked GABA-A receptor a3-subunit gene
Linkage simulations
Mapping
Microsatellites

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10.1038/npp.1993.40

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title = "Linkage of fifty-seven microsatellite loci to bipolar disorder",

abstract = "ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.",

keywords = "Bipolar illness, GNASl, Human X-linked GABA-A receptor a3-subunit gene, Linkage simulations, Mapping, Microsatellites",

author = "Gejman, \{Pablo V.\} and Maria Martinez and Qiuhe Cao and Eitan Friedman and Berrettini, \{Wade H.\} and Goldin, \{Lynn R.\} and Panayiota Koroulakis and Chris Ames and Lerman, \{Melissa A.\} and Gershon, \{Elliot S.\}",

year = "1993",

month = aug,

doi = "10.1038/npp.1993.40",

language = "אנגלית",

volume = "9",

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journal = "Neuropsychopharmacology",

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T1 - Linkage of fifty-seven microsatellite loci to bipolar disorder

AU - Gejman, Pablo V.

AU - Martinez, Maria

AU - Cao, Qiuhe

AU - Friedman, Eitan

AU - Berrettini, Wade H.

AU - Goldin, Lynn R.

AU - Koroulakis, Panayiota

AU - Ames, Chris

AU - Lerman, Melissa A.

AU - Gershon, Elliot S.

PY - 1993/8

Y1 - 1993/8

N2 - ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.

AB - ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.

KW - Bipolar illness

KW - GNASl

KW - Human X-linked GABA-A receptor a3-subunit gene

KW - Linkage simulations

KW - Mapping

KW - Microsatellites

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JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

IS - 1

ER -

Linkage of fifty-seven microsatellite loci to bipolar disorder

Abstract

Keywords

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