Linkage of fifty-seven microsatellite loci to bipolar disorder

Pablo V. Gejman*, Maria Martinez, Qiuhe Cao, Eitan Friedman, Wade H. Berrettini, Lynn R. Goldin, Panayiota Koroulakis, Chris Ames, Melissa A. Lerman, Elliot S. Gershon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalNeuropsychopharmacology
Volume9
Issue number1
DOIs
StatePublished - Aug 1993
Externally publishedYes

Keywords

  • Bipolar illness
  • GNASl
  • Human X-linked GABA-A receptor a3-subunit gene
  • Linkage simulations
  • Mapping
  • Microsatellites

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