Abstract
ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.
Original language | English |
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Pages (from-to) | 31-40 |
Number of pages | 10 |
Journal | Neuropsychopharmacology |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - Aug 1993 |
Externally published | Yes |
Keywords
- Bipolar illness
- GNASl
- Human X-linked GABA-A receptor a3-subunit gene
- Linkage simulations
- Mapping
- Microsatellites