Linkage of fifty-seven microsatellite loci to bipolar disorder

Pablo V. Gejman, Maria Martinez, Qiuhe Cao, Eitan Friedman, Wade H. Berrettini, Lynn R. Goldin, Panayiota Koroulakis, Chris Ames, Melissa A. Lerman, Elliot S. Gershon

Research output: Contribution to journalArticlepeer-review

Abstract

ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalNeuropsychopharmacology
Volume9
Issue number1
DOIs
StatePublished - Aug 1993
Externally publishedYes

Keywords

  • Bipolar illness
  • GNASl
  • Human X-linked GABA-A receptor a3-subunit gene
  • Linkage simulations
  • Mapping
  • Microsatellites

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