Linkage of fifty-seven microsatellite loci to bipolar disorder

Pablo V. Gejman; Maria Martinez; Qiuhe Cao; Eitan Friedman; Wade H. Berrettini; Lynn R. Goldin; Panayiota Koroulakis; Chris Ames; Melissa A. Lerman; Elliot S. Gershon

doi:10.1038/npp.1993.40

Linkage of fifty-seven microsatellite loci to bipolar disorder

Pablo V. Gejman, Maria Martinez, Qiuhe Cao, Eitan Friedman, Wade H. Berrettini, Lynn R. Goldin, Panayiota Koroulakis, Chris Ames, Melissa A. Lerman, Elliot S. Gershon

Research output: Contribution to journal › Article › peer-review

Abstract

ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.

Original language	English
Pages (from-to)	31-40
Number of pages	10
Journal	Neuropsychopharmacology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/npp.1993.40
State	Published - Aug 1993
Externally published	Yes

Keywords

Bipolar illness
GNASl
Human X-linked GABA-A receptor a3-subunit gene
Linkage simulations
Mapping
Microsatellites

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/npp.1993.40

Cite this

@article{90aa89e5e49c4a5ca5d54c0daa674ff3,

title = "Linkage of fifty-seven microsatellite loci to bipolar disorder",

abstract = "ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.",

keywords = "Bipolar illness, GNASl, Human X-linked GABA-A receptor a3-subunit gene, Linkage simulations, Mapping, Microsatellites",

author = "Gejman, {Pablo V.} and Maria Martinez and Qiuhe Cao and Eitan Friedman and Berrettini, {Wade H.} and Goldin, {Lynn R.} and Panayiota Koroulakis and Chris Ames and Lerman, {Melissa A.} and Gershon, {Elliot S.}",

year = "1993",

month = aug,

doi = "10.1038/npp.1993.40",

language = "אנגלית",

volume = "9",

pages = "31--40",

journal = "Neuropsychopharmacology",

issn = "0893-133X",

publisher = "Nature Publishing Group",

number = "1",

}

Linkage of fifty-seven microsatellite loci to bipolar disorder. / Gejman, Pablo V.; Martinez, Maria; Cao, Qiuhe; Friedman, Eitan; Berrettini, Wade H.; Goldin, Lynn R.; Koroulakis, Panayiota; Ames, Chris; Lerman, Melissa A.; Gershon, Elliot S.

In: Neuropsychopharmacology, Vol. 9, No. 1, 08.1993, p. 31-40.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Linkage of fifty-seven microsatellite loci to bipolar disorder

AU - Gejman, Pablo V.

AU - Martinez, Maria

AU - Cao, Qiuhe

AU - Friedman, Eitan

AU - Berrettini, Wade H.

AU - Goldin, Lynn R.

AU - Koroulakis, Panayiota

AU - Ames, Chris

AU - Lerman, Melissa A.

AU - Gershon, Elliot S.

PY - 1993/8

Y1 - 1993/8

N2 - ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.

AB - ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.

KW - Bipolar illness

KW - GNASl

KW - Human X-linked GABA-A receptor a3-subunit gene

KW - Linkage simulations

KW - Mapping

KW - Microsatellites

UR - http://www.scopus.com/inward/record.url?scp=0027186031&partnerID=8YFLogxK

U2 - 10.1038/npp.1993.40

DO - 10.1038/npp.1993.40

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 8397721

AN - SCOPUS:0027186031

VL - 9

SP - 31

EP - 40

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 1

ER -

Linkage of fifty-seven microsatellite loci to bipolar disorder

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this