Linkage between sexual orientation and chromosome Xq28 in males but not in females

Stella Hu, Angela M.L. Pattatucci, Chavis Patterson, Lin Li, David W. Fulker, Stacey S. Cherny, Leonid Kruglyak, Dean H. Hamer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We have extended our analysis of the role of the long arm of the X chromosome (Xq28) in sexual orientation by DNA linkage analyses of two newly ascertained series of families that contained either two gay brothers or two lesbian sisters as well as heterosexual siblings. Linkage between the Xq28 markers and sexual orientation was detected for the gay male families but not for the lesbian families or for families that failed to meet defined inclusion criteria for the study of sex–linked sexual orientation. Our results corroborate the previously reported linkage between Xq28 and male homosexuality in selected kinships and suggest that this region contains a locus that influences individual variations in sexual orientation in men but not in women.

Original languageEnglish
Pages (from-to)248-256
Number of pages9
JournalNature Genetics
Issue number3
StatePublished - Nov 1995
Externally publishedYes


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